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The application of ecological theory toward an understanding of the human microbiome.

Summary of "The application of ecological theory toward an understanding of the human microbiome."

The human-microbial ecosystem plays a variety of important roles in human health and disease. Each person can be viewed as an island-like "patch" of habitat occupied by microbial assemblages formed by the fundamental processes of community ecology: dispersal, local diversification, environmental selection, and ecological drift. Community assembly theory, and metacommunity theory in particular, provides a framework for understanding the ecological dynamics of the human microbiome, such as compositional variability within and between hosts. We explore three core scenarios of human microbiome assembly: development in infants, representing assembly in previously unoccupied habitats; recovery from antibiotics, representing assembly after disturbance; and invasion by pathogens, representing assembly in the context of invasive species. Judicious application of ecological theory may lead to improved strategies for restoring and maintaining the microbiota and the crucial health-associated ecosystem services that it provides.

Affiliation

Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Journal Details

This article was published in the following journal.

Name: Science (New York, N.Y.)
ISSN: 1095-9203
Pages: 1255-62

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Medical and Biotech [MESH] Definitions

Ongoing collection, analysis, and interpretation of ecological data that is used to assess changes in the components, processes, and overall condition and functioning of an ECOSYSTEM.

Ecological and environmental entities, characteristics, properties, relationships and processes.

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An interdisciplinary study dealing with the transmission of messages or signals, or the communication of information. Information theory does not directly deal with meaning or content, but with physical representations that have meaning or content. It overlaps considerably with communication theory and CYBERNETICS.

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