The application of ecological theory toward an understanding of the human microbiome.

11:44 EDT 22nd August 2014 | BioPortfolio

Summary of "The application of ecological theory toward an understanding of the human microbiome."

The human-microbial ecosystem plays a variety of important roles in human health and disease. Each person can be viewed as an island-like "patch" of habitat occupied by microbial assemblages formed by the fundamental processes of community ecology: dispersal, local diversification, environmental selection, and ecological drift. Community assembly theory, and metacommunity theory in particular, provides a framework for understanding the ecological dynamics of the human microbiome, such as compositional variability within and between hosts. We explore three core scenarios of human microbiome assembly: development in infants, representing assembly in previously unoccupied habitats; recovery from antibiotics, representing assembly after disturbance; and invasion by pathogens, representing assembly in the context of invasive species. Judicious application of ecological theory may lead to improved strategies for restoring and maintaining the microbiota and the crucial health-associated ecosystem services that it provides.

Affiliation

Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Journal Details

This article was published in the following journal.

Name: Science (New York, N.Y.)
ISSN: 1095-9203
Pages: 1255-62

Links

PubMed Articles [22637 Associated PubMed Articles listed on BioPortfolio]

The role of metagenomics in understanding the human microbiome in health and disease.

The term "microbiome" refers to the genetic material of the catalog of microbial taxa associated with humans. As in all ecosystems, the microbiota reaches a dynamic equilibrium in the human body, whic...

A Clinician's Primer on the Role of the Microbiome in Human Health and Disease.

The importance of the commensal microbiota that colonizes the skin, gut, and mucosal surfaces of the human body is being increasingly recognized through a rapidly expanding body of science studying th...

The Microbiome and Development: A Mother's Perspective.

Dysbiosis of the microbiome has been associated with type II diabetes mellitus, obesity, inflammatory bowel disorders, and colorectal cancer, and recently, the Human Microbiome Project Consortium has...

The portrayal of natural environment in the evolution of the ecological public health paradigm.

This paper explores the conceptualization of the natural environment in an evolving ecological public health paradigm. The natural environment has long been recognized as essential to supporting life,...

Manipulation of the intestinal microbiome in newborn infants.

The mammalian gastrointestinal tract harbors a highly diverse microbial population termed the microbiome, which plays a major role in nutrition, metabolism, protection against pathogens, and developme...

Clinical Trials [2349 Associated Clinical Trials listed on BioPortfolio]

Controlled Feeding Experiment

The purpose of this study is to determine the effect of dietary fat, in standard formulation, on the composition of the human microbiome in a prospective study of normal volunteers. Partic...

Metagenomic Analysis of Gut Microbiome in Korean Patients With Ulcerative Colitis

The researchers will investigate gut microbiome in Korean patients with ulcerative colitis and normal control subjects using metagenomic analysis to elucidate the significant difference be...

Study of the Human Skin Microbiome

Numerous organisms live on and in healthy human skin. This study seeks to survey the diversity of this complex ecosystem by collecting samples from approximately 1000 individuals in order...

The Effect of Intranasal Administration of Oxytocin on Empathic Abilities.

Empathy constitutes one prominent ability of social cognition, which represents the human capability of understanding mental state of the other, and responding in sympathetic way. Two sets...

A Multi-Center Protocol for Obtaining and Storing Human Samples for Immediate or Future Microbial, Immune, or Host-Microbe Scientific Study

The intent of this protocol is to salvage human-related material that is normally destined for destruction, so it can be used in infection-related scientific studies. This clinical materia...

Medical and Biotech [MESH] Definitions

Ecological and environmental entities, characteristics, properties, relationships and processes.

The act or fact of grasping the meaning, nature, or importance of; understanding. (American Heritage Dictionary, 4th ed) Includes understanding by a patient or research subject of information disclosed orally or in writing.

Component of the NATIONAL INSTITUTES OF HEALTH. It was initially established to investigate the broad aspects of human development as a means of understanding developmental disabilities, including mental retardation, and the events that occur during pregnancy. It now conducts and supports research on all stages of human development. It was established in 1962.

An interdisciplinary study dealing with the transmission of messages or signals, or the communication of information. Information theory does not directly deal with meaning or content, but with physical representations that have meaning or content. It overlaps considerably with communication theory and CYBERNETICS.

Methods, procedures, and tests performed in the laboratory with an intended application to the diagnosis of disease or understanding of physiological functioning. The techniques include examination of microbiological, cytological, chemical, and biochemical specimens, normal and pathological.

Search BioPortfolio: