Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer.
Summary of "Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer."
Evaluation of: Valle J, Wasan H, Palmer DH et al. Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N. Engl. J. Med. 362, 1273-1281 (2010). Biliary tract cancer is a rare disease and it is associated with a poor clinical outcome and survival. A standard therapy has not been established yet. The evaluated article reports on the first Phase III randomized controlled multicenter trial (ABC-02 trial) on palliative chemotherapy for biliary tract cancer. A total of 410 patients with locally advanced or metastatic cholangiocarcinoma, gallbladder cancer or ampullary cancer were included to receive either cisplatin followed by gemcitabine or gemcitabine alone for up to 24 weeks. The primary end point was overall survival and the secondary end point was progression-free survival. The median overall survival was 11.7 months in the cisplatin plus gemcitabine group and 8.1 months in the gemcitabine only group. The median progression-free survival was 8.0 months in the cisplatin plus gemcitabine group and 5.0 months in the gemcitabine-only group (p < 0.001). Adverse events were comparable in the two groups. Cisplatin plus gemcitabine, compared with gemcitabine alone, was associated with a significant survival advantage without an increase in substantial toxicity.
Affiliation
Otto-v-Guericke University Magdeburg, Magdeburg, Germany.
Journal Details
This article was published in the following journal.
Name: Expert review of gastroenterology & hepatology
ISSN: 1747-4132
Pages: 395-7
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20678012
- DOI: http://dx.doi.org/10.1586/egh.10.45
Medical and Biotech [MESH] Definitions
Biliary Tract Neoplasms
Tumors or cancer in the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.
Biliary Fistula
Abnormal passage in any organ of the biliary tract or between biliary organs and other organs.
Biliary Tract Diseases
Diseases in any part of the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.
Cholangitis, Sclerosing
Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.
Biliary Tract Surgical Procedures
Any surgical procedure performed on the biliary tract.
PubMed Articles
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