Identification of mineral deposits in the brain on radiological images: a systematic review.

21:59 EST 28th February 2015 | BioPortfolio

Summary of "Identification of mineral deposits in the brain on radiological images: a systematic review."


OBJECTIVES:
MRI has allowed the study of mineral deposition in the brain throughout life and in disease. However, studies differ in their reporting of minerals on MRI for reasons that are unclear.
METHODS:
We conducted a systematic review from 1985 to July 2011 to determine the appearance of iron, calcium, copper and manganese on MRI and CT and their reliability. We assessed which imaging investigations provided the most consistent results compared with histology.
RESULTS:
Of 325 papers on minerals imaging, we included 46 studies that confirmed findings either directly or indirectly using a non-imaging method such as histology. Within this group, there was inconsistency in the identification of iron probably because of changes in its paramagnetic properties during its degradation. Iron appeared consistently hypointense only on T2*-weighted MRI, and along with calcified areas, hyperattenuated on CT. Appearance of copper, calcium and manganese, although consistently reported as hyperintense on T1-weighted MRI, was confirmed histologically in few studies. On T2-weighted imaging, calcified areas were always reported as hypointense, while the appearance of iron depended on the concentration, location and degradation stage.
CONCLUSIONS:
More work is required to improve the reliability of imaging methods to detect and differentiate brain mineral deposition accurately. KEY POINTS : • There is inconsistency in reporting the appearance of minerals on radiological images. • Only 46 studies confirmed mineral appearance using a non-imaging method. • Iron is the mineral more widely studied, consistently hypointense on T2*-weighted MRI. • T1-weighted MRI consistently reported copper, calcium and manganese hyperintense. • Calcium is consistently reported hypointense on T2-weighted MRI and hyperattenuating on CT.

Affiliation

Brain Research Imaging Centre, Department of Clinical Neurosciences, University of Edinburgh, Edinburgh, UK, mvhernan@staffmail.ed.ac.uk.

Journal Details

This article was published in the following journal.

Name: European radiology
ISSN: 1432-1084
Pages:

Links

PubMed Articles [26885 Associated PubMed Articles listed on BioPortfolio]

Can dental cone beam computed tomography assess bone mineral density?

Mineral density distribution of bone tissue is altered by active bone modeling and remodeling due to bone complications including bone disease and implantation surgery. Clinical cone beam computed tom...

FDG and 82Rb PET/MRI Features of Brain Metastasis of Breast Cancer.

A 64-year-old female patient with stage IV breast cancer underwent an FDG and Rb PET brain studies. The PET brain images were fused with MRI brain T1 post-contrast images. The known enhancing left sup...

Meniscal allograft transplantation in a symptomatic meniscal deficient knee: a systematic review.

The primary objective of this study was to perform an updated systematic review and meta-analysis of meniscal allograft transplantation using patient reported outcome measures at final follow-up as th...

Integrated Tele-radiological and Tele-pathological Evaluation of Pulmonary Grafts for Reducing the Rate of Injured and Diseased Grafts, in Lung Transplant.

Aim: Feasibility and reliability assessment of the integrated Tele-Radiological (TRE) and Tele-Pathological (TPE) evaluation of the Pulmonary Graft (PG) on Telemedicine Systems, in Lung Transplant (LT...

MTA and Ferric Sulfate in Pulpotomy Outcomes of Primary Molars: A Systematic Review and Meta-Analysis.

Methods of systematic review and meta analysis were employed to compare the success rate of pulpotomy of primary molars using mineral trioxide aggregate (MTA) and ferric sulfate (FS) as two regenerati...

Clinical Trials [3295 Associated Clinical Trials listed on BioPortfolio]

Identification of Clinically Occult Glioma Cells and Characterization of Glioma Behavior Through Machine Learning Analysis of Advanced Imaging Technology

Gliomas are one of the most challenging tumors to treat, because areas of the apparently normal brain contain microscopic deposits of glioma cells; indeed, these occult cells are known to ...

Dose Finding Study of Gadovist in Central Nervous System (CNS) Magnetic Resonance Imaging (MRI)

The purpose of this study is to look at the safety (what are the side effects) and efficacy (how well does it work) of Gadovist when used for taking images of the brain and spine. The res...

Effect of Systematic Medication Review in Elderly Patients Admitted to an Orthopedic Department

Elderly patients have a higher risk of experiencing adverse drug events due to an age related increase in morbidity and medication use. Inappropriate or wrong medication use among elderly ...

A Systematic Review on the Accuracy and Reliability the BodyGem/MedGem Metabolic Devices

With the number of individuals becoming overweight or obese, healthcare professionals are in need of accurate, reliable, and convenient tools to help personalize weight loss programs. Rece...

Identification of Genes Expressed in Atherosclerotic Plaque

This study will identify genes and proteins in the blood of patients with atherosclerosis and in that of normal volunteers. The findings will be compared to determine the influence of thes...

Medical and Biotech [MESH] Definitions

The electronic transmission of radiological images from one location to another for the purposes of interpretation and/or consultation. Users in different locations may simultaneously view images with greater access to secondary consultations and improved continuing education. (From American College of Radiology, ACR Standard for Teleradiology, 1994, p3)

Review of the medical necessity of hospital or other health facility admissions, upon or within a short time following an admission, and periodic review of services provided during the course of treatment.

The systematic study of the structure and function of the complete set of glycans (the glycome) produced in a single organism and identification of all the genes that encode glycoproteins.

Systematic identification of a population's needs or the assessment of individuals to determine the proper level of services needed.

The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.

Search BioPortfolio:
Loading
Advertisement

Relevant Topics

Alzheimer's Disease
Latest News Clinical Trials Research Drugs Reports Corporate
Of all the types of Dementia, Alzheimer's disease is the most common, affecting around 465,000 people in the UK. Neurons in the brain die, becuase  'plaques' and 'tangles' (mis-folded proteins) form in the brain. People with Al...

Radiology
Latest News Clinical Trials Research Drugs Reports Corporate
Radiology is the branch of medicine that studies imaging of the body; X-ray (basic, angiography, barium swallows), ultrasound, MRI, CT and PET. These imaging techniques can be used to diagnose, but also to treat a range of conditions, by allowing visuali...

Advertisement