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Diet, nutrients, phytochemicals, and cancer metastasis suppressor genes.

06:00 EDT 14th June 2012 | BioPortfolio

Summary of "Diet, nutrients, phytochemicals, and cancer metastasis suppressor genes."

The major factor in the morbidity and mortality of cancer patients is metastasis. There exists a relative lack of specific therapeutic approaches to control metastasis, and this is a fruitful area for investigation. A healthy diet and lifestyle not only can inhibit tumorigenesis but also can have a major impact on cancer progression and survival. Many chemicals found in edible plants are known to inhibit metastatic progression of cancer. While the mechanisms underlying antimetastatic activity of some phytochemicals are being delineated, the impact of diet, dietary components, and various phytochemicals on metastasis suppressor genes is underexplored. Epigenetic regulation of metastasis suppressor genes promises to be a potentially important mechanism by which dietary components can impact cancer metastasis since many dietary constituents are known to modulate gene expression. The review addresses this area of research as well as the current state of knowledge regarding the impact of diet, dietary components, and phytochemicals on metastasis suppressor genes.

Affiliation

Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, P. O. Box 646510, Pullman, WA, 99164-6510, USA, meadows@wsu.edu.

Journal Details

This article was published in the following journal.

Name: Cancer metastasis reviews
ISSN: 1573-7233
Pages:

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