Insight into pressure drop dependent efficiencies of dry powder inhalers.
Summary of "Insight into pressure drop dependent efficiencies of dry powder inhalers."
The purpose of this study was to assess the effectiveness of three commercial capsule-based dry powder passive inhalers [Rotahaler® (RH), Monodose Inhaler® (MI) and Handihaler® (HH)] in de-agglomerating salbutamol sulphate (SS) and micronized lactose (LH300) powders and their sensitivity to air flow rate changes and air flow resistance.
Affiliation
Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Journal Details
This article was published in the following journal.
Name: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
ISSN: 1879-0720
Pages: 142-8
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22586728
- DOI: http://dx.doi.org/
Medical and Biotech [MESH] Definitions
Dry Powder Inhalers
A device that delivers medication to the lungs in the form of a dry powder.
Hypotension, Orthostatic
A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.
Instillation, Drug
The administration of therapeutic agents drop by drop, as eye drops, ear drops, or nose drops. It is also administered into a body space or cavity through a catheter. It differs from irrigation in that the irrigate is removed within minutes, but the instillate is left in place.
Powder Diffraction
Method of using a polycrystalline powder and Rietveld refinement (LEAST SQUARES ANALYSIS) of X-RAY DIFFRACTION or NEUTRON DIFFRACTION. It circumvents the difficulties of producing single large crystals.
Venous Pressure
The blood pressure in the VEINS. It is usually measured to assess the filling PRESSURE to the HEART VENTRICLE.
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