Safety of Oligonol, A Highly Bioavailable Lychee-Derived Polyphenolic Antioxidant, on Liver, Kidney & Heart Functionin Rats.
Summary of "Safety of Oligonol, A Highly Bioavailable Lychee-Derived Polyphenolic Antioxidant, on Liver, Kidney & Heart Functionin Rats."
Abstract Oligonol (OLG), derived from lychee fruit, is a novel compound produced from the oligomerization of polyphenols. In this study, the acute effect of OLG treatment was investigated on heart, liver and kidneyin rats. OLG treatment at two different doses (15 or 30 mg/kg body weight) and two different time points (1day or 7 days of treatment) demonstrated that no toxic effects were observed on heart, liver and renal functions. Moreover, OLG did not induce any DNA damage or oxidative stress as measured by 8-hydroxy-2'-deoxyguanosine levels in plasma. OLG supplementation increased the phosphorylation of myocardial endothelial nitric oxide level (p-eNOS) in both the treatment groups. Even the low dose OLG treatment (15mg/kg b.w) demonstrated an increase in p-eNOS/eNOS ratio after normalization of p-eNOS values with eNOS on day 1 (1.5-fold) and day 7 (2.2-fold) groups as compared to control. The above results suggest that OLG treatment increases endothelial nitric oxide levels and may play a role in nitric oxide-mediated vasodilatory effects without adverse side effects on cardiovascular function. This endothelial NO production may underlie the beneficial effect of OLG in cardiovascular health.
Affiliation
University of Connecticut Health Center, Department of Surgery, Molecular Cardiology and Angiogenesis Laboratory, Farmington, CT, USA;
Journal Details
This article was published in the following journal.
Name: Toxicology mechanisms and methods
ISSN: 1537-6524
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22694591
- DOI: http://dx.doi.org/10.3109/15376516.2012.702795
Medical and Biotech [MESH] Definitions
Safety
Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.
Sulfur Dioxide
A highly toxic, colorless, nonflammable gas. It is used as a pharmaceutical aid and antioxidant. It is also an environmental air pollutant.
Food Safety
Activities involved in ensuring the safety of FOOD including avoidance of bacterial and other contamination.
United States Occupational Safety And Health Administration
An office in the Department of Labor responsible for developing and establishing occupational safety and health standards.
National Institute For Occupational Safety And Health (u.s.)
An institute of the CENTERS FOR DISEASE CONTROL AND PREVENTION which is responsible for assuring safe and healthful working conditions and for developing standards of safety and health. Research activities are carried out pertinent to these goals.
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