Safety of Oligonol, A Highly Bioavailable Lychee-Derived Polyphenolic Antioxidant, on Liver, Kidney & Heart Functionin Rats.
Summary of "Safety of Oligonol, A Highly Bioavailable Lychee-Derived Polyphenolic Antioxidant, on Liver, Kidney & Heart Functionin Rats."
Abstract Oligonol (OLG), derived from lychee fruit, is a novel compound produced from the oligomerization of polyphenols. In this study, the acute effect of OLG treatment was investigated on heart, liver and kidneyin rats. OLG treatment at two different doses (15 or 30 mg/kg body weight) and two different time points (1day or 7 days of treatment) demonstrated that no toxic effects were observed on heart, liver and renal functions. Moreover, OLG did not induce any DNA damage or oxidative stress as measured by 8-hydroxy-2'-deoxyguanosine levels in plasma. OLG supplementation increased the phosphorylation of myocardial endothelial nitric oxide level (p-eNOS) in both the treatment groups. Even the low dose OLG treatment (15mg/kg b.w) demonstrated an increase in p-eNOS/eNOS ratio after normalization of p-eNOS values with eNOS on day 1 (1.5-fold) and day 7 (2.2-fold) groups as compared to control. The above results suggest that OLG treatment increases endothelial nitric oxide levels and may play a role in nitric oxide-mediated vasodilatory effects without adverse side effects on cardiovascular function. This endothelial NO production may underlie the beneficial effect of OLG in cardiovascular health.
University of Connecticut Health Center, Department of Surgery, Molecular Cardiology and Angiogenesis Laboratory, Farmington, CT, USA;
This article was published in the following journal.
Name: Toxicology mechanisms and methods
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22694591
- DOI: http://dx.doi.org/10.3109/15376516.2012.702795
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