Craniovertebral junction pathology in high cervical disc disease.
Summary of "Craniovertebral junction pathology in high cervical disc disease."
Objective. To establish predisposing factors of high cervical disc degeneration (HCDD) with an emphasis on the presence or absence of craniovertebral junction (CVJ) pathology by a retrospective analysis of clinical and radiologic parameters of patients operated at our institute. Methods. Thirty-seven patients of C3-4 prolapsed intervertebral disc (PIVD) were compared with 45 patients of C5-6 PIVD. Nurick's grade was used for clinical assessment. Radiological parameters like congenital and osteoarthritic changes at CVJ along with measurement of stress levels in flexion and extension on X-rays were done. Results. Mean age of C3-4 PIVD patients (48.16 years, range 26-65 years) was significantly higher than C5-6 PIVD patients (38.13 years, range 21-55 years) (p < 0.001). CVJ pathology was seen in significantly higher proportion in patients with C3-4 PIVD (18/37) in comparison to C5-6 PIVD (4/45) (p < 0.001). C3-4 PIVD patients presented with a poorer pre-op and post-op Nurick's grade. T2 hyperintense intramedullary signal change was seen in 91.8% (34/37) of C3-4 PIVD patients as compared to 66.67% (30/45) of C5-6 PIVD patients (p < 0.001). Conclusion. CVJ pathology is a predisposing factor for HCDD. HCDD presents in a poorer Nurick's grade compared to lower cervical PIVD and majority of the patients have T2 hyperintense intramedullary signal changes in MRI. Presence of T2 hyperintense intramedullary signal changes is associated with poorer pre-op clinical status and poorer post-op outcome.
Department of Neurosurgery, National Institute of Mental Health and Neurosciences (NIMHANS) , Bangalore , India.
This article was published in the following journal.
Name: British journal of neurosurgery
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22698391
- DOI: http://dx.doi.org/10.3109/02688697.2012.690918
Low backache (LBA) is one of the most common problems and herniated lumbar disc is one of the most commonly diagnosed abnormalities associated with LBA. Disc herniation of the same size may be asympto...
Neurenteric cysts at the craniovertebral junction are extremely rare, in that most are located ventrally in the midline. We report two patients with neurenteric cysts in an unusual location - the late...
Retrospective review of the case file.
CHARGE syndrome is a common cause of congenital anomalies. Its rate of incidence is about 1:10,000. It is phenotypically heterogeneous, usually a sporadic or autosomal dominant disorder resulting from...
The function of the upper cervical spine (UCS) is essential in the kinematics of the whole cervical spine. Specific motion patterns are described at the UCS during head motions to compensate coupled m...
The purpose of this study is to establish the safety and effectiveness of the Advent™ Cervical Disc compared to Anterior Cervical Discectomy and Fusion (ACDF) in treating degenerative di...
The purpose of this clinical trial is to evaluate the safety and effectiveness of the PRESTIGE® LP Cervical Disc as a method of treating patients with symptoms of cervical degenerative di...
The purpose of this study is to determine the safety and effectiveness of the DISCOVER Artificial Cervical Disc in the treatment of degenerative disc disease in one level in the cervical s...
The purpose of the study is to evaluate the safety and effectiveness of the SECURE®-C Cervical Artificial Disc for the treatment of symptomatic cervical disc disease at one level between...
The purpose of the study is to evaluate the performance of the Discover cervical Artificial disc in the treatment of degenerative disc disease in one level of the cervical spine.
Medical and Biotech [MESH] Definitions
A malignancy arising in uterine cervical epithelium and confined thereto, representing a continuum of histological changes ranging from well-differentiated CIN 1 (formerly, mild dysplasia) to severe dysplasia/carcinoma in situ, CIN 3. The lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive epidermoid carcinoma, a tendency that is enhanced by concomitant human papillomaviral infection. (Segen, Dictionary of Modern Medicine, 1992)
Electrophoresis in which discontinuities in both the voltage and pH gradients are introduced by using buffers of different composition and pH in the different parts of the gel column. The term 'disc' was originally used as an abbreviation for 'discontinuous' referring to the buffers employed, and does not have anything to do with the shape of the separated zones.
A network of nerve fibers originating in the upper four cervical spinal cord segments. The cervical plexus distributes cutaneous nerves to parts of the neck, shoulders, and back of the head, and motor fibers to muscles of the cervical spinal column, infrahyoid muscles, and the diaphragm.
A specialty concerned with the nature and cause of disease as expressed by changes in cellular or tissue structure and function caused by the disease process.
A parameter usually used in PRENATAL ULTRASONOGRAPHY to measure the length of the uterine neck (CERVIX UTERI). Cervical length or its shortening is used to identify and prevent early cervical opening and PRETERM BIRTH.