Advertisement

Topics

Craniovertebral junction pathology in high cervical disc disease.

06:00 EDT 16th June 2012 | BioPortfolio

Summary of "Craniovertebral junction pathology in high cervical disc disease."

Objective. To establish predisposing factors of high cervical disc degeneration (HCDD) with an emphasis on the presence or absence of craniovertebral junction (CVJ) pathology by a retrospective analysis of clinical and radiologic parameters of patients operated at our institute. Methods. Thirty-seven patients of C3-4 prolapsed intervertebral disc (PIVD) were compared with 45 patients of C5-6 PIVD. Nurick's grade was used for clinical assessment. Radiological parameters like congenital and osteoarthritic changes at CVJ along with measurement of stress levels in flexion and extension on X-rays were done. Results. Mean age of C3-4 PIVD patients (48.16 years, range 26-65 years) was significantly higher than C5-6 PIVD patients (38.13 years, range 21-55 years) (p < 0.001). CVJ pathology was seen in significantly higher proportion in patients with C3-4 PIVD (18/37) in comparison to C5-6 PIVD (4/45) (p < 0.001). C3-4 PIVD patients presented with a poorer pre-op and post-op Nurick's grade. T2 hyperintense intramedullary signal change was seen in 91.8% (34/37) of C3-4 PIVD patients as compared to 66.67% (30/45) of C5-6 PIVD patients (p < 0.001). Conclusion. CVJ pathology is a predisposing factor for HCDD. HCDD presents in a poorer Nurick's grade compared to lower cervical PIVD and majority of the patients have T2 hyperintense intramedullary signal changes in MRI. Presence of T2 hyperintense intramedullary signal changes is associated with poorer pre-op clinical status and poorer post-op outcome.

Affiliation

Department of Neurosurgery, National Institute of Mental Health and Neurosciences (NIMHANS) , Bangalore , India.

Journal Details

This article was published in the following journal.

Name: British journal of neurosurgery
ISSN: 1360-046X
Pages:

Links

DeepDyve research library

PubMed Articles [34428 Associated PubMed Articles listed on BioPortfolio]

171 Resurgery in Craniovertebral Junction Abnormalities.

Surgery for craniovertebral junction (CVJ) abnormalities like atlantoaxial dislocation (AAD) with or without basilar invagination (BI) and/or with or without associated Arnold-Chiari malformation (ACM...

Anterior cervical discectomy and fusion (ACDF) versus cervical disc arthroplasty (CDA) for two contiguous levels cervical disc degenerative disease: a meta-analysis of randomized controlled trials.

Anterior cervical discectomy and fusion (ACDF) has been considered as a gold standard for symptomatic cervical disc degeneration (CDD), which may result in progressive degeneration of the adjacent seg...

Comparison of Outcomes of Single-Level Anterior Cervical Discectomy With Fusion and Single-Level Artificial Cervical Disc Replacement for Single-Level Cervical Degenerative Disc Disease.

A single-center, prospective comparative study of prospectively collected outcomes, with a minimum 12 months follow-up.

Hybrid Corpectomy and Disc Arthroplasty for Cervical Spondylotic Myelopathy Caused by Ossification of Posterior Longitudinal Ligament and Disc Herniation.

Combination of ACDF and ACCF (Anterior cervical discectomy or corpectomy with fusion) has been demonstrated to be effective for multi-level CSM (cervical spondylotic myelopathy). However, the combinat...

Percutaneous Cervical Nucleoplasty Versus Pulsed Radio Frequency of the Dorsal Root Ganglion in Patients with Contained Cervical Disc Herniation; A Prospective, Randomized Controlled Trial.

Cervical neck pain is often caused by cervical disc pathology and may cause severe symptoms and disability. Surgeons as well as patients are increasingly aware of postsurgery-related complications. Th...

Clinical Trials [7111 Associated Clinical Trials listed on BioPortfolio]

Advent™ Cervical Disc Versus Anterior Cervical Discectomy and Fusion(ACDF) for Treatment of One Level Degenerative Disc Disease (IDE Study)

The purpose of this study is to establish the safety and effectiveness of the Advent™ Cervical Disc compared to Anterior Cervical Discectomy and Fusion (ACDF) in treating degenerative di...

Study of Safety & Effectiveness of PRESTIGE® LP Cervical Disc vs. Anterior Cervical Fusion in Cervical Degenerative Disc Disease

The purpose of this clinical trial is to evaluate the safety and effectiveness of the PRESTIGE® LP Cervical Disc as a method of treating patients with symptoms of cervical degenerative di...

Comparison of DISCOVER™ Artificial Cervical Disc and ACDF for Treatment of Cervical DDD (IDE Study)

The purpose of this study is to determine the safety and effectiveness of the DISCOVER Artificial Cervical Disc in the treatment of degenerative disc disease in one level in the cervical s...

A Clinical Trial Evaluating a Total Disc Replacement in Patients With Cervical Disc Disease

This study will be a non-randomized trial consisting of patients with single level (C3 to C7) symptomatic cervical disc disease who have not previously received fusion surgery at the same ...

An Investigation of the Metal Concentration in Patients Implanted With the PRESTIGE LP™ Cervical Disc at Two Contiguous Levels in the Cervical Spine

This clinical study will assess the metal concentrations present in the blood serum of patients who receive surgical treatment with the PRESTIGE LP™ Cervical Disc at two contiguous cervi...

Medical and Biotech [MESH] Definitions

A malignancy arising in uterine cervical epithelium and confined thereto, representing a continuum of histological changes ranging from well-differentiated CIN 1 (formerly, mild dysplasia) to severe dysplasia/carcinoma in situ, CIN 3. The lesion arises at the squamocolumnar cell junction at the transformation zone of the endocervical canal, with a variable tendency to develop invasive epidermoid carcinoma, a tendency that is enhanced by concomitant human papillomaviral infection. (Segen, Dictionary of Modern Medicine, 1992)

Electrophoresis in which discontinuities in both the voltage and pH gradients are introduced by using buffers of different composition and pH in the different parts of the gel column. The term 'disc' was originally used as an abbreviation for 'discontinuous' referring to the buffers employed, and does not have anything to do with the shape of the separated zones.

A network of nerve fibers originating in the upper four cervical spinal cord segments. The cervical plexus distributes cutaneous nerves to parts of the neck, shoulders, and back of the head, and motor fibers to muscles of the cervical spinal column, infrahyoid muscles, and the diaphragm.

A specialty concerned with the nature and cause of disease as expressed by changes in cellular or tissue structure and function caused by the disease process.

A parameter usually used in PRENATAL ULTRASONOGRAPHY to measure the length of the uterine neck (CERVIX UTERI). Cervical length or its shortening is used to identify and prevent early cervical opening and PRETERM BIRTH.

Quick Search
Advertisement
 


DeepDyve research library

Relevant Topics

Stress
Stress is caused by your perception of situations around you and then the reaction of your body to them. The automatic stress response to unexpected events is known as 'fight or flight'. Discovered by Walter Cannon in 1932, it is the release of h...

Radiology
Radiology is the branch of medicine that studies imaging of the body; X-ray (basic, angiography, barium swallows), ultrasound, MRI, CT and PET. These imaging techniques can be used to diagnose, but also to treat a range of conditions, by allowing visuali...

Neurology - Central Nervous System (CNS)
Alzheimer's Disease Anesthesia Anxiety Disorders Autism Bipolar Disorders Dementia Epilepsy Multiple Sclerosis (MS) Neurology Pain Parkinson's Disease Sleep Disorders Neurology is the branch of me...


Searches Linking to this Article