C-h functionalization.
Summary of "C-h functionalization."
No Summary Available
Affiliation
University of Maryland.
Journal Details
This article was published in the following journal.
Name: Accounts of chemical research
ISSN: 1520-4898
Pages: 777
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22709449
- DOI: http://dx.doi.org/10.1021/ar300096z
Medical and Biotech [MESH] Definitions
Metabolic Detoxication, Phase I
Functionalization of exogenous substances to prepare them for conjugation in PHASE II DETOXIFICATION. Phase I enzymes include CYTOCHROME P450 enzymes and some OXIDOREDUCTASES. Excess induction of phase I over phase II detoxification leads to higher levels of FREE RADICALS that can induce CANCER and other cell damage. Induction or antagonism of phase I detoxication is the basis of a number of DRUG INTERACTIONS.
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Clinical Trials
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