Factors affecting mechanical (nociceptive) thresholds in piglets.
Summary of "Factors affecting mechanical (nociceptive) thresholds in piglets."
Objectiveâ€‚ To evaluate the stability and repeatability of measures of mechanical (nociceptive) thresholds in piglets and to examine potentially confounding factors when using a hand held algometer. Study designâ€‚ Descriptive, prospective cohort. Animalsâ€‚ Forty-four piglets from four litters, weighing 4.6â€ƒÂ±â€ƒ1.0â€ƒkg (meanâ€ƒÂ±â€ƒSD) at 2â€ƒweeks of age. Methodsâ€‚ Mechanical thresholds were measured twice on each of 2â€ƒdays during the first and second week of life. Data were analyzed using a repeated measures design to test the effects of behavior prior to testing, sex, week, day within week, and repetition within day. The effect of body weight and the interaction between piglet weight and behaviour were also tested. Piglet was entered into the model as a random effect as an additional test of repeatability. The effect of repeated testing was used to test the stability of measures. Pearson correlations between repeated measures were used to test the repeatability of measures. Variance component analysis was used to describe the variability in the data. Resultsâ€‚ Variance component analysis indicated that piglet explained only 17% of the variance in the data. All variables in the model (behaviour prior to testing, sex, week, day within week, repetition within day, body weight, the interaction between body weight and behaviour, piglet identity) except sex had a significant effect (pâ€ƒ<â€ƒ0.04 for all). Correlations between repeated measures increased from the first to the second week. Conclusions and Clinical relevanceâ€‚ Repeatability was acceptable only during the second week of testing and measures changed with repeated testing and increased with increasing piglet weight, indicating that time (age) and animal body weight should be taken into account when measuring mechanical (nociceptive) thresholds in piglets. Mechanical (nociceptive) thresholds can be used both for testing the efficacy of anaesthetics and analgesics, and for assessing hyperalgesia in chronic pain states in research and clinical settings.
Department of Production Animal Clinical Sciences, The Norwegian School of Veterinary Science, Oslo, Norway Department of Pharmacology and Toxicology, The Norwegian School of Veterinary Science, Oslo, Norway.
This article was published in the following journal.
Name: Veterinary anaesthesia and analgesia
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22709378
- DOI: http://dx.doi.org/10.1111/j.1467-2995.2012.00737.x
Medical and Biotech [MESH] Definitions
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