Childhood Abuse and Inflammatory Responses to Daily Stressors.
Summary of "Childhood Abuse and Inflammatory Responses to Daily Stressors."
Childhood abuse leads to greater morbidity and mortality in adulthood. Dysregulated physiological stress responses may underlie the greater health risk among abused individuals.
This study evaluated the impact of childhood abuse on inflammatory responses to naturalistically occurring daily stressors.
In this cross-sectional study of 130 older adults, recent daily stressors and childhood abuse history were evaluated using the Daily Inventory of Stressful Events and the Childhood Trauma Questionnaire. Blood samples provided data on circulating interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP).
Childhood abuse history moderated IL-6 levels but not TNF-α and CRP responses to daily stressors. Individuals with a childhood abuse history who experienced multiple stressors in the past 24 h had IL-6 levels 2.35 times greater than those of participants who reported multiple daily stressors but no early abuse history.
Childhood abuse substantially enhances IL-6 responses to daily stressors in adulthood.
Department of Psychology, Concordia University, 7141 Sherbrooke Street West, PY 170-14, Montréal, Québec, Canada, H4B 1R6, email@example.com.
This article was published in the following journal.
Name: Annals of behavioral medicine : a publication of the Society of Behavioral Medicine
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22714139
- DOI: http://dx.doi.org/10.1007/s12160-012-9386-1
Medical and Biotech [MESH] Definitions
A constellation of responses that occur when an organism is exposed to excessive heat and other environmental stressors. Responses include synthesis of some proteins, repression of other proteins, and expression of new proteins. (From Segen, Dictionary of Modern Medicine, 1992)
The time period of daily exposure that an organism receives from daylight or artificial light. It is believed that photoperiodic responses may affect the control of energy balance and thermoregulation.
Coordinate set of non-specific behavioral responses to non-psychiatric illness. These may include loss of APPETITE or LIBIDO; disinterest in ACTIVITIES OF DAILY LIVING; or withdrawal from social interaction.
Abuse of children in a family, institutional, or other setting. (APA, Thesaurus of Psychological Index Terms, 1994)
A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.
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