Coordination between RAB GTPase and phosphoinositide regulation and functions.
Summary of "Coordination between RAB GTPase and phosphoinositide regulation and functions."
Membrane trafficking relies on dynamic changes in membrane identities that are determined by the regulation of distinct RAB GTPases and phosphoinositides. RABs and phosphoinositides both act to spatiotemporally recruit effectors of membrane remodelling, including sequential RAB and phosphoinositide activities. New ideas on coordinated regulation of specific RABs and phosphoinositides, achieved by direct physical and functional interactions between their regulatory enzymes, are emerging as a central mechanism to ensure precision and fidelity of membrane trafficking.
Affiliation
Section of Cell and Developmental Biology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0380, USA.
Journal Details
This article was published in the following journal.
Name: Nature reviews. Molecular cell biology
ISSN: 1471-0080
Pages: 463-70
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22722608
- DOI: http://dx.doi.org/10.1038/nrm3379
Medical and Biotech [MESH] Definitions
Neurofibromin 1
A protein found most abundantly in the nervous system. Defects or deficiencies in this protein are associated with NEUROFIBROMATOSIS 1, Watson syndrome, and LEOPARD syndrome. Mutations in the gene (GENE, NEUROFIBROMATOSIS 1) affect two known functions: regulation of ras-GTPase and tumor suppression.
Sodium-hydrogen Antiporter
A plasma membrane exchange glycoprotein transporter that functions in intracellular pH regulation, cell volume regulation, and cellular response to many different hormones and mitogens.
Gtpase-activating Proteins
Proteins that activate the GTPase of specific GTP-BINDING PROTEINS.
P120 Gtpase Activating Protein
A 120-kDa RAS GTPase-activating protein that binds to tyrosine phosphoproteins through its SH2 domains. The 100-kDa RNA-splicing variant (p100 GAP protein) is expressed in placenta.
Coordination Complexes
Neutral or negatively charged ligands bonded to metal cations or neutral atoms. The number of ligand atoms to which the metal center is directly bonded is the metal cation's coordination number, and this number is always greater than the regular valence or oxidation number of the metal. A coordination complex can be negative, neutral, or positively charged.
PubMed Articles
The large GTPase dynamin has an important membrane scission function in receptor-mediated endocytosis and other cellular processes. Self-assembly on phosphoinositide-containing membranes stimulates dy...
The chemical biology of phosphoinositide 3-kinases.
Since its discovery in the late 1980s, phosphoinositide 3-kinase (PI3K), and its isoforms have arguably reached the forefront of signal transduction research. Regulation of this lipid kinase, its func...
Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions.
Reversible phosphoinositide phosphorylation provides a dynamic membrane code that balances opposing cell functions. However, in vivo regulatory relationships between specific kinases, phosphatases, an...
Phosphoinositide 3-kinase γ (PI3Kγ) signaling engaged by β-adrenergic receptors is pivotal in the regulation of myocardial contractility and remodeling. However, the role of PI3Kγ in catecholamine...
Inositol polyphosphate 5-phosphatases; new players in the regulation of cilia and ciliopathies.
Phosphoinositides regulate numerous cellular events via the recruitment and activation of multiple lipid-binding effector proteins. The precise temporal and spatial regulation of phosphoinositide sign...
Clinical Trials
Proprioception and Eye-head Coordination for the Cervical Spine
Specific aims of this project were as follows: 1. To investigate the eye-head coordination of patients with cervical spine degeneration. 2. To investigate the relationship of these i...
Telephone Care Coordination for Smokers in VA Mental Health Clinics
The purpose of this study is to evaluate whether a smoking cessation telephone care coordination program is effective and feasible in VA Mental Health Clinics.
Adaptive Coordination in Anaesthesia Teams and Its Relationship to Clinical Performance.
The impact of different coordination patterns on team performance during anesthesia inductions are analyzed using videotapes. These records are examined using various categorization system...
The purpose of this pilot study is to determine whether incorporating self-regulation training using daily weighing is efficacious within a behavioral weight loss program specifically targ...
A Nutritional Approach to Minimal Hepatic Encephalopathy
This trial will study a possible effect of standard Israeli breakfast (30% of caloric value and 21 gram protein) on cognitive and executive functions (working memory, visual memory, concen...
