Metastasis: Exosomes drive premetastatic niche formation.
Summary of "Metastasis: Exosomes drive premetastatic niche formation."
No Summary Available
Affiliation
Journal Details
This article was published in the following journal.
Name: Nature reviews. Cancer
ISSN: 1474-1768
Pages: 447
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22722393
- DOI: http://dx.doi.org/10.1038/nrc3304
Medical and Biotech [MESH] Definitions
Drive
A state of internal activity of an organism that is a necessary condition before a given stimulus will elicit a class of responses; e.g., a certain level of hunger (drive) must be present before food will elicit an eating response.
Stem Cell Niche
A particular zone of tissue composed of a specialized microenvironment where stem cells are retained in a undifferentiated, self-renewable state.
Thirst
A drive stemming from a physiological need for WATER.
Exosomes
Vesicles secreted from MULTIVESICULAR BODIES into the extracellular environment when the multivesicular bodies fuse with the PLASMA MEMBRANE. Multivesicular bodies are formed from ENDOSOMES when they accumulate vesicles (sometimes referred to as "intraluminal vesicles") from inward budding of the endosome membrane.
Type A Personality
Established behavior pattern characterized by excessive drive and ambition, impatience, competitiveness, sense of time urgency, and poorly contained aggression.
PubMed Articles
Metastasis: STAT3 promotes premetastatic niche formation.
Exosomes in tumor microenvironment influence cancer progression and metastasis.
Exosomes are small membrane vesicles of endocytic origin with a size of 50-100 nm. They can contain microRNAs, mRNAs, DNA fragments, and proteins, which are shuttled from a donor cell to recipient ce...
The mechanisms by which a primary tumor affects a selected distant organ before tumor cell arrival remain to be elucidated. This report shows that Gr-1+CD11b+ cells are significantly increased in lung...
S1PR1-STAT3 Signaling Is Crucial for Myeloid Cell Colonization at Future Metastatic Sites.
Recent studies underscore the importance of myeloid cells in rendering distant organs hospitable for disseminating tumor cells to colonize. However, what enables myeloid cells to have an apparently su...
Intratumoral hypoxia, a frequent finding in metastatic cancer, results in the activation of hypoxia-inducible factors (HIFs). HIFs are implicated in many steps of breast cancer metastasis, including m...
Clinical Trials
Loco-regionally advanced nasopharyngeal carcinoma (NPC)(stage III, IV in UICC 2002 Classification) can be divided into two groups according to the risk of metastasis: high-risk metastasis...
Validation of a Molecular Prognostic Test for Eye Melanoma
Up to half of patients with ocular melanoma (also called iris, choroidal or uveal melanoma) develop metastasis. We have found that certain molecular features of the eye tumor can be detect...
RATIONALE: Stereotactic body radiation therapy may be able to send x-rays directly to the tumor and cause less damage to normal tissue. Vertebroplasty may help prevent fractures and spinal...
Asymptomatic Brain Metastasis in Non-small Cell Lung Cancer (NSCLC)
The prognosis of NSCLC patients with asymptomatic brain metastasis, who are not treated with SRS or WBRT has not been fully investigated yet. This randomized phase III trial is conducted t...
Study of XL999 in Patients With Metastatic Colorectal Cancer
This clinical study is being conducted at multiple sites to determine the activity, safety, and tolerability of XL999 when given weekly to patients with metastatic colorectal cancer (CRC)....
