Radiotherapy and Bevacizumab for intramedullary and leptomenigeal metastatic Glioblastoma: a case report and review of the literature.
Summary of "Radiotherapy and Bevacizumab for intramedullary and leptomenigeal metastatic Glioblastoma: a case report and review of the literature."
Abstract Glioblastoma (GBM) developed metastases rarely and the prognosis, in these cases, was very poor. We reported a 30-year patient who, developing intramedullary and leptomeningeal metastases from GBM, underwent palliative spinal radiotherapy and Bevacizumab.
Affiliation
1Department Radiotherapy Oncology, IRCCS/CROB , Rionero in Vulture (PZ) , Italy.
Journal Details
This article was published in the following journal.
Name: The International journal of neuroscience
ISSN: 1563-5279
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22720749
- DOI: http://dx.doi.org/10.3109/00207454.2012.704456
Medical and Biotech [MESH] Definitions
Spinal Cord Neoplasms
Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
Radiotherapy, Adjuvant
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Fatal Outcome
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
Radiotherapy Dosage
The total amount of radiation absorbed by tissues as a result of radiotherapy.
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
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