The effect of admission hyperglycemia in stroke patients treated with thrombolysis.
Summary of "The effect of admission hyperglycemia in stroke patients treated with thrombolysis."
Abstract Background: Acute hyperglycemia has been shown to correlate negatively with outcome in stroke patients yet the mechanism remains controversial. The aim of our study is to study the immediate and long term effects of admission hyperglycemia on outcome in a cohort of stroke patients treated with thrombolytic therapy Methods: We reviewed the prospective dataset of a statewide telestroke network for the characteristics of 195 patients who received intravenous tissue plasminogen activator via telemedicine during a 27-months period. We compared outcome and improvement rate of patients with and without hyperglycemia. We defined good outcome as a modified Rankin Scale score ≤ 2 and neurological improvement after thrombolysis as either a decrease in NIHSS at 24 hours by 5 points from baseline or an NIHSS of 0 at 24 hours Results: Thirty-one percent of patients had admission hyperglycemia (Blood sugar > 144). Patients with admission hyperglycemia (HG) had higher 3 month mortality and poor outcome rates than those without (NG). The improvement rates with thrombolysis however, were similar between the two groups. Conclusions: Admission hyperglycemia is associated with poor neurological recovery in patients with acute stroke despite thrombolytic treatment without having an effect on the clinical response to thrombolytic therapy. Larger studies are needed to confirm this finding.
1Department of Neurology, University of Arkansas for Medical Sciences.
This article was published in the following journal.
Name: The International journal of neuroscience
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22720729
- DOI: http://dx.doi.org/10.3109/00207454.2012.702820
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