Microrough Cobalt-Chromium Alloy Surfaces for Paclitaxel Delivery: Preparation, Characterization, and In Vitro Drug Release Studies.

Summary of "Microrough Cobalt-Chromium Alloy Surfaces for Paclitaxel Delivery: Preparation, Characterization, and In Vitro Drug Release Studies."

Cobalt-chromium (Co-Cr) alloys have extensive biomedical applications including drug-eluting stents (DES). This study investigates the use of eight different microrough Co-Cr alloy surfaces for delivering paclitaxel (PAT) for potential use in DES. The eight different surfaces include four bare microrough and four self-assembled monolayers (SAMs) coated microrough surfaces. The bare microrough surfaces were prepared by grit blasting Co-Cr with glass beads (50 and 100 µm in sizes), and Al2O3 (50 and 110 µm). The SAMs coated surfaces were prepared by depositing a -COOH terminated phosphonic acid monolayer on the different microrough surfaces. PAT was then deposited on all the bare and SAMs coated microrough surfaces. The surfaces were characterized using scanning electron microscopy (SEM), 3D optical profilometry, and Fourier transform infrared spectroscopy (FTIR). SEM showed the different morphologies of microrough surfaces without and with PAT coating. Optical profiler showed the 3D topography of the different surfaces and the changes in surface roughness and surface area after SAMs and PAT deposition. FTIR showed ordered SAMs were formed on glass bead grit blasted surfaces while the molecules were disordered on Al2O3 grit blasted surfaces. Also, FTIR showed the successful deposition of PAT on these surfaces. The PAT release was investigated for up to two weeks using high performance liquid chromatography. Al2O3 grit blasted bare microrough surfaces showed sustained release profiles while the glass bead grit blasted surfaces showed burst release profiles. All SAMs coated surfaces showed biphasic drug release profiles which is an initial burst release followed by a slow and sustained release. SAMs coated Al2O3 grit blasted surfaces prolonged the sustained release of PAT in significant amount during the second week of drug elution studies while this behavior was not observed for any other surfaces used in this study. Thus, this study demonstrates the use of different microrough Co-Cr alloy surfaces for delivering PAT for potential applications in DES and other medical devices.

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Journal Details

This article was published in the following journal.

Name: Langmuir : the ACS journal of surfaces and colloids
ISSN: 1520-5827
Pages:

Links

• PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22720656
• DOI: http://dx.doi.org/10.1021/la301636z