Formulation of novel nano-encapsulated Newcastle disease vaccine tablets for vaccination of village chickens.
Summary of "Formulation of novel nano-encapsulated Newcastle disease vaccine tablets for vaccination of village chickens."
Formulation of nano-encapsulated vaccine tablet is a novel technique for the delivery of Newcastle disease (ND) vaccine to village chickens. Vaccine tablets were prepared using gelatin, trehalose and casein as thermostabilisers and binders, respectively, and each vaccine tablet contained a nominal oral dose of Newcastle disease virus (NDV) strain I-2 for a single chicken. These ND vaccine tablets maintained a titre of 10(8.5) EID(50)/0.1 mL for 90 days at ambient room temperatures (25-34 degrees C). When these vaccine tablets were given to village chickens, a single oral administration of the vaccine produced protective antibody response (>/=3.0 log(2)) against challenge with virulent NDV. The findings from the present study showed that, if the vaccine tablet formulation technique is optimised, it will allow the delivery of the ND vaccine without depending on cold chains to rural areas in tropical countries.
Affiliation
Department of Veterinary Microbiology and Parasitology, Sokoine University of Agriculture, P.O. Box 3019, Chuo Kikuu, Morogoro, Tanzania, phil_wambura@yahoo.com.
Journal Details
This article was published in the following journal.
Name: Tropical animal health and production
ISSN: 1573-7438
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20683657
- DOI: http://dx.doi.org/10.1007/s11250-010-9669-0
Medical and Biotech [MESH] Definitions
Newcastle Disease
An acute febrile, contagious, viral disease of birds caused by an AVULAVIRUS called NEWCASTLE DISEASE VIRUS. It is characterized by respiratory and nervous symptoms in fowl and is transmissible to man causing a severe, but transient conjunctivitis.
Tablets, Enteric-coated
Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
Diphtheria-tetanus Vaccine
A combined vaccine used to prevent infection with diphtheria and tetanus toxoid. This is used in place of DTP vaccine (DIPHTHERIA-TETANUS-PERTUSSIS VACCINE) when PERTUSSIS VACCINE is contraindicated.
Avulavirus
A genus in the subfamily PARAMYXOVIRINAE, family PARAMYXOVIRIDAE, causing disease in domestic fowl. There are many species, the most well-known being avian paramyxovirus 1 (NEWCASTLE DISEASE VIRUS).
Poliovirus Vaccine, Oral
A live vaccine containing attenuated poliovirus, types I, II, and III, grown in monkey kidney cell tissue culture, used for routine immunization of children against polio. This vaccine induces long-lasting intestinal and humoral immunity. Killed vaccine induces only humoral immunity. Oral poliovirus vaccine should not be administered to immunocompromised individuals or their household contacts. (Dorland, 28th ed)
PubMed Articles
Immunological adjuvant efficacy of glycyrrhetinic acid liposome against Newcastle disease vaccine.
The aim of this study is to investigate whether the activity of inducing immune response of glycyrrhetinic acid (GA) could be enhanced after GA was encapsulated with liposome. Three hundred and fifty...
Nystatin is commonly employed to treat fungal infections in the mouth. It is not absorbed via the stomach and it will therefore not treat fungal infections in any part of the body other than the mouth...
Design and evaluation of a new formulation of enalapril maleate tablet.
Enalapril maleate, one of the Angiotensin converting enzyme (ACE) inhibitor is effective in the treatment of hypertension. Enalapril maleate is selected for the present study. The aim of this study wa...
The aim of the present study was to develop asymmetric membrane (AM) tablets for controlled delivery of highly water-soluble antihistaminic drug triprolidine hydrochloride. The solubility of triprolid...
Clinical Trials
Liposome Encapsulated SN38 (LE-SN38) in Patients With Advanced Cancer
Liposome Encapsulated SN38 (LE-SN38) is an oncology drug product consisting of the active metabolite of irinotecan (CPT-11), a known anticancer drug, encapsulated in a liposome. Formulatio...
Bioequivalence Study of Zidovudine 300 mg Tablets, USP Under Fasting Conditions
The purpose of this study is to evaluate the relative bioavailability of the test formulation of Zidovudine 300 mg tablets with an already marketed reference formulation RETROVIR ® 300 mg...
Bioequivalence Study of Sertraline Hydrochloride 100mg Tablets Under Fasting Conditions
The purpose of this study was to evaluate the relative bioavailability of the test formulation of sertraline 100 mg tablets with an already marketed reference formulation Zoloft® 100 mg t...
Proof-of Concept Study of Topical 3%-Diclofenac-Nano-Emulsion Cream for Knee OA Pain
This study valuates the safety and efficacy of treatment with 3% Diclofenac Nano-Emulsion Cream versus Placebo in subjects with osteoarthritis of the knee.
This study is in support of the annual application for the variation of the vaccine strains for a marketing authorisation. Objectives: - To evaluate compliance, in terms of immu...
