Formulation of novel nano-encapsulated Newcastle disease vaccine tablets for vaccination of village chickens.
Summary of "Formulation of novel nano-encapsulated Newcastle disease vaccine tablets for vaccination of village chickens."
Formulation of nano-encapsulated vaccine tablet is a novel technique for the delivery of Newcastle disease (ND) vaccine to village chickens. Vaccine tablets were prepared using gelatin, trehalose and casein as thermostabilisers and binders, respectively, and each vaccine tablet contained a nominal oral dose of Newcastle disease virus (NDV) strain I-2 for a single chicken. These ND vaccine tablets maintained a titre of 10(8.5) EID(50)/0.1 mL for 90 days at ambient room temperatures (25-34 degrees C). When these vaccine tablets were given to village chickens, a single oral administration of the vaccine produced protective antibody response (>/=3.0 log(2)) against challenge with virulent NDV. The findings from the present study showed that, if the vaccine tablet formulation technique is optimised, it will allow the delivery of the ND vaccine without depending on cold chains to rural areas in tropical countries.
Department of Veterinary Microbiology and Parasitology, Sokoine University of Agriculture, P.O. Box 3019, Chuo Kikuu, Morogoro, Tanzania, email@example.com.
This article was published in the following journal.
Name: Tropical animal health and production
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20683657
- DOI: http://dx.doi.org/10.1007/s11250-010-9669-0
Medical and Biotech [MESH] Definitions
An acute febrile, contagious, viral disease of birds caused by an AVULAVIRUS called NEWCASTLE DISEASE VIRUS. It is characterized by respiratory and nervous symptoms in fowl and is transmissible to man causing a severe, but transient conjunctivitis.
Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
A combined vaccine used to prevent infection with diphtheria and tetanus toxoid. This is used in place of DTP vaccine (DIPHTHERIA-TETANUS-PERTUSSIS VACCINE) when PERTUSSIS VACCINE is contraindicated.
A genus in the subfamily PARAMYXOVIRINAE, family PARAMYXOVIRIDAE, causing disease in domestic fowl. There are many species, the most well-known being avian paramyxovirus 1 (NEWCASTLE DISEASE VIRUS).
Poliovirus Vaccine, Oral
A live vaccine containing attenuated poliovirus, types I, II, and III, grown in monkey kidney cell tissue culture, used for routine immunization of children against polio. This vaccine induces long-lasting intestinal and humoral immunity. Killed vaccine induces only humoral immunity. Oral poliovirus vaccine should not be administered to immunocompromised individuals or their household contacts. (Dorland, 28th ed)
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