Brain targeting of Atorvastatin loaded amphiphilic PLGA-b-PEG nanoparticles.
Summary of "Brain targeting of Atorvastatin loaded amphiphilic PLGA-b-PEG nanoparticles."
The objective of this study was to develop polysorbate 80 coated and Atorvastatin loaded poly(lactic-co-glycolic acid)-block-poly(ethylene glycol) (PLGA-b-PEG) nanoparticles and to investigate advantages of coating on nanoparticles for brain delivery of Atorvastatin. The nanoparticles were prepared by nanoprecipitation method. The effects of polymer concentration, PEG content and polysorbate 80 coating on the particle size, drug loading efficiency and release behaviour of nanoparticles were investigated. Additionally, cellular uptake and brain targeting of formulated nanoparticles were studied. Particle sizes were in the range of 30-172 nm depending on formulation parameters. Increasing the polymer concentration significantly increased the nanoparticle size. Decreasing the PEG content from 15% to 5% (w/w) in polymer composition increased the nanoparticle size from 69 to 172 nm. Both coated and uncoated polysorbate 80 nanoparticles were effectively internalised within the endothelial cells. Moreover, both types of nanoparticles were able to penetrate the blood brain barrier and reach the maximum in brain 1 h post injection. It was concluded that these nanoparticles are promising nanosystems for treatment of neurological disorders.
Department of Basic Pharmaceutical Science, Faculty of Pharmacy, Hacettepe University , 06100 Sıhhiye/Ankara-Turkey.
This article was published in the following journal.
Name: Journal of microencapsulation
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22734433
- DOI: http://dx.doi.org/10.3109/02652048.2012.692400
Medical and Biotech [MESH] Definitions
Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.
Nanoparticles produced from metals whose uses include biosensors, optics, and catalysts. In biomedical applications the particles frequently involve the noble metals, especially gold and silver.
Compounds that provide LUBRICATION between surfaces in order to reduce FRICTION. They are typically LIPIDS, and include lipophilic lotions, but not EYEDROPS which are aqueous, nor SURFACE-ACTIVE AGENTS which are amphiphilic surfactants.
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