Craniopharyngioma: history.
Summary of "Craniopharyngioma: history."
One of the most challenging parasellar tumors, the craniopharyngioma was first described by Friedrich Albert von Zenker in 1857. Following improved understanding of pituitary gland physiology and development, Jakob Erdheim became the first to accurately describe the histopathological characteristics of a craniopharyngioma. Babinski's described the clinical presentation of these patients, with "sexual infantilism and dystrophic adiposity." The first successful surgical resection of a craniopharyngioma was performed by A. E. Halstead of Chicago of July 21st, 1909. Harvey Cushing embraced the transsphenoidal approach for the majority of his pituitary operations, but favored the transcranial approach for craniopharyngiomas. The introduction of antibiotics, corticosteroids, and microscopy significantly improved surgical outcomes. As technology improved, trans-cranial and transsphenoidal approaches were implemented depending on tumor characteristics. Adjuvant therapy, such as stereotactic radiosurgery, radioisotope brachytherapy, and intracapsular chemotherapy have improved overall tumor control rates and decreased the incidence of complications. Building on over 100 years of surgery for "the most formidable of intracranial tumors," results continue to improve. Regardless, challenges continue to remain requiring surgical insight and innovation.
Affiliation
Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, 15 Francis St. PBB3, Boston, MA, 02115, USA, Garni.barkhoudarian@gmail.com.
Journal Details
This article was published in the following journal.
Name: Pituitary
ISSN: 1573-7403
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22744873
- DOI: http://dx.doi.org/10.1007/s11102-012-0402-z
Medical and Biotech [MESH] Definitions
Craniopharyngioma
A benign pituitary-region neoplasm that originates from Rathke's pouch. The two major histologic and clinical subtypes are adamantinous (or classical) craniopharyngioma and papillary craniopharyngioma. The adamantinous form presents in children and adolescents as an expanding cystic lesion in the pituitary region. The cystic cavity is filled with a black viscous substance and histologically the tumor is composed of adamantinomatous epithelium and areas of calcification and necrosis. Papillary craniopharyngiomas occur in adults, and histologically feature a squamous epithelium with papillations. (From Joynt, Clinical Neurology, 1998, Ch14, p50)
Philology
The study of literature in its widest sense, including grammar, etymology, criticism, literary history, language history, linguistic history, systems of writing, and anything else that is relevant to literature or language viewed as literature. Philology as a discipline has both philosophical and scientific overtones.
History, Medieval
The period of history from the year 500 through 1450 of the common era.
History, Ancient
The period of history before 500 of the common era.
Philology, Classical
The study of ancient Greek and Roman literature, including grammar, etymology, criticism, literary history, and language and linguistic history.
PubMed Articles
Craniopharyngioma is a frequent tumor in children with challenging surgical, endocrine, and visual consequences. We evaluated our experience in treating craniopharyngioma and its incidence in Macedoni...
Spontaneous rupture of craniopharyngioma is a rare condition described mainly in adults. Chemical meningitis or improvements in clinical symptomatology are the usual events heralding such rupture. Spo...
De novo malignant craniopharyngioma: case report and literature review.
Malignant or anaplastic craniopharyngioma, first described in 1987 by Akachi and coworkers, is a rare occurring craniopharyngioma characterized by cytologic atypia and poor prognosis. Fifteen cases ha...
All-trans retinoic acid inhibits craniopharyngioma cell growth: study on an explant cell model.
The ratio between FABP5 and CRABPII determines cellular response to physiological level of retinoic acid; tumor cells undergo proliferation with high level of FABP5 and apoptosis with high level of CR...
Functional analysis and treatment of aggressive behavior following resection of a craniopharyngioma.
Craniopharyngioma is a relatively rare, benign tumor that most often affects pre-adolescent children. Surgical resection is a common form of treatment, which may result in adverse physical, neurologic...
Clinical Trials
Observation of Young Patients Who Are Undergoing Surgery for Craniopharyngioma
RATIONALE: Collecting information on how craniopharyngioma is diagnosed and treated may help doctors predict a patient's response to treatment and help plan the best treatment. It may also...
Tumor Classification and Its Application in Surgical Treatment of Craniopharyngioma
With the preliminary anatomical and histological study, the membranous structures of the sellar region was considered to be closely related with the growth pattern of Craniopharyngiomas(CP...
Goodness of Clinical History During Stemi PCI
The purpose of this study is to confirm or confute the hypothesis that in patients treated with primary pci is not always possible to collect an adequate medical history, the investigators...
T-Cell Project: Epidemiologic Component
Background: - The T-Cell Project, sponsored by the International T-cell non-Hodgkin Lymphoma Study Group, is a consortium of institutions interested in achieving more detailed...
A Natural History Study of Patients With Dry Eye
This is a multi-center, prospective, controlled, observational study of the natural history of patients with dry eye disease.
