Predictors of symptomatic remission in first-episode psychosis outpatients treated with quetiapine: a naturalistic study.
Summary of "Predictors of symptomatic remission in first-episode psychosis outpatients treated with quetiapine: a naturalistic study."
Abstract Objectives: The aim of this naturalistic study was to assess course and predictors of symptomatic remission in outpatients with first-episode psychosis during quetiapine monotherapy. Methods: In 131 outpatients presenting with first-episode psychosis socio-demographic and clinical variables including PANSS-8 and CGI-S scores were compared at baseline and follow-up between the subgroups with and without symptomatic remission during 12 weeks of flexible-dose treatment with quetiapine. Results: Logistic regression revealed a low degree of negative symptoms at baseline, younger age, shorter duration of psychotic episode, early treatment response and the absence of concomitant diseases as predictors for symptomatic remission whereas general disease severity, PANSS-8 total score, gender, alcohol or substance abuse had no predictive value. Conclusions: Our study underlines the predictive value of early treatment response and a low degree of negative symptoms in outpatients with first-episode psychosis. It also confirms the usability of the symptomatic remission criterion as a cross-sectional threshold criterion in clinical practice.
Affiliation
Journal Details
This article was published in the following journal.
Name: International journal of psychiatry in clinical practice
ISSN: 1471-1788
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22746987
- DOI: http://dx.doi.org/10.3109/13651501.2012.704384
Medical and Biotech [MESH] Definitions
Remission Induction
Therapeutic act or process that initiates a response to a complete or partial remission level.
Busulfan
An alkylating agent having a selective immunosuppressive effect on BONE MARROW. It has been used in the palliative treatment of chronic myeloid leukemia (MYELOID LEUKEMIA, CHRONIC), but although symptomatic relief is provided, no permanent remission is brought about. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), busulfan is listed as a known carcinogen.
Acute Coronary Syndrome
An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode but that does not usually result in MYOCARDIAL INFARCTION.
Outpatients
Persons who receive ambulatory care at an outpatient department or clinic without room and board being provided.
Heat Stress Disorders
A group of conditions due to overexposure to or overexertion in excess environmental temperature. It includes heat cramps, which are non-emergent and treated by salt replacement; HEAT EXHAUSTION, which is more serious, treated with fluid and salt replacement; and HEAT STROKE, a condition most commonly affecting extremes of age, especially the elderly, accompanied by convulsions, delusions, or coma and treated with cooling the body and replacement of fluids and salts. (From Segen, Dictionary of Modern Medicine, 1992)
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