Preparation and characterisation of multilayer films and microcapsules containing poly(N-isopropylacrylamide-co-sodium vinylsulphonate) and applicability on controlled release.
Summary of "Preparation and characterisation of multilayer films and microcapsules containing poly(N-isopropylacrylamide-co-sodium vinylsulphonate) and applicability on controlled release."
The copolymers of N-isopropylacrylamide and sodium vinylsulphonate were synthesised by free radical polymerisation. The layer-by-layer self-assembly of the copolymers with poly(allylamine) hydrochloride was performed through assembling onto silicon wafer to form multilayer films and onto CaCO(3) microparticles doped with poly(styrene sulphonate) as well as deltamethrin microcrystals to form microcapsules. The multilayer films and microcapsules were characterised by atomic force microscopy, transmission electron microscopy and scanning electron microscopy. The release behaviour of deltamethrin in the microcapsules under different conditions was also investigated by high performance liquid chromatography. Results show that these deltamethrin microcapsules have good thermo-sensitive properties and deltamethrin release can be controlled via changing temperature or self-assembly layers.
Affiliation
Key Laboratory of Special Functional Aggregated Materials, Ministry of Education, Shandong University , Jinan 250100 , P.R. China.
Journal Details
This article was published in the following journal.
Name: Journal of microencapsulation
ISSN: 1464-5246
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22746547
- DOI: http://dx.doi.org/10.3109/02652048.2012.700958
Medical and Biotech [MESH] Definitions
Poly(a)-binding Protein Ii
A poly(A) binding protein that is involved in promoting the extension of the poly A tails of MRNA. The protein requires a minimum of ten ADENOSINE nucleotides in order for binding to mRNA. Once bound it works in conjunction with CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR to stimulate the rate of poly A synthesis by POLY A POLYMERASE. Once poly-A tails reach around 250 nucleotides in length poly(A) binding protein II no longer stimulates POLYADENYLATION. Mutations within a GCG repeat region in the gene for poly(A) binding protein II have been shown to cause the disease MUSCULAR DYSTROPHY, OCULOPHARYNGEAL.
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Poly(a)-binding Protein I
A poly(A) binding protein that has a variety of functions such as mRNA stabilization and protection of RNA from nuclease activity. Although poly(A) binding protein I is considered a major cytoplasmic RNA-binding protein it is also found in the CELL NUCLEUS and may be involved in transport of mRNP particles.
Polyadenylation
The addition of a tail of polyadenylic acid (POLY A) to the 3' end of mRNA (RNA, MESSENGER). Polyadenylation involves recognizing the processing site signal, (AAUAAA), and cleaving of the mRNA to create a 3' OH terminal end to which poly A polymerase (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) adds 60-200 adenylate residues. The 3' end processing of some messenger RNAs, such as histone mRNA, is carried out by a different process that does not include the addition of poly A as described here.
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