Metastatic adenocarcinoma of mammary-like glands of the vulva successfully treated with surgery and hormonal therapy.
Summary of "Metastatic adenocarcinoma of mammary-like glands of the vulva successfully treated with surgery and hormonal therapy."
Vulvar cancer is a rare malignancy; most tumors are squamous cell type while adenocarcinomas are rare. Primary adenocarcinomas of the vulva predominantly include extramammary Paget's disease and sweat gland carcinomas. Greene first described a rare form of adenocarcinoma in 1936, which was called adenocarcinoma of mammary-like glands of the vulva because of its morphologic and immunohistochemical resemblance to breast adenocarcinomas. In the management of this entity, varying combinations of surgery, radiation therapy, systemic chemotherapy and/or hormonal therapy may be used, as in patients with orthotopic breast carcinoma. However, hormonal therapy leads the way in patients with positive hormonal receptors, where other therapies cannot be used due to comorbidities or advanced age. We present the first reported case of an elderly patient with metastatic vulvar adenocarcinoma arising from mammary-like glands, successfully treated with a combination of surgery and hormonal therapy.
Departments of Gynecologic Oncology Pathology, Hospital Universitario Materno-Infantil de Canarias, Las Palmas de Gran Canaria, Spain.
This article was published in the following journal.
Name: The journal of obstetrics and gynaecology research
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22764738
- DOI: http://dx.doi.org/10.1111/j.1447-0756.2012.01937.x
Medical and Biotech [MESH] Definitions
Mammary Glands, Animal
MAMMARY GLANDS in the non-human MAMMALS.
Mammary Neoplasms, Animal
Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).
Mammary Tumor Virus, Mouse
The type species of BETARETROVIRUS commonly latent in mice. It causes mammary adenocarcinoma in a genetically susceptible strain of mice when the appropriate hormonal influences operate.
Mammary Glands, Human
Glandular tissue in the BREAST of human that is under the influence of hormones such as ESTROGENS; PROGESTINS; and PROLACTIN. In WOMEN, after PARTURITION, the mammary glands secrete milk (MILK, HUMAN) for the nourishment of the young.
An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)
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