Suzuki-Miyaura Coupling Reactions of Iodo(difluoroenol) Derivatives, Fluorinated Building Blocks Accessible at Near-ambient Temperatures.
Summary of "Suzuki-Miyaura Coupling Reactions of Iodo(difluoroenol) Derivatives, Fluorinated Building Blocks Accessible at Near-ambient Temperatures."
A recently developed method for the near-ambient generation of difluorovinylzinc reagents has facilitated the preparation of 1-(N,N-diethylcarbamoyloxy)-2,2-difluoro-1-iodoethene and 1-(2'-methoxy-ethoxymethoxy)-2,2-difluoro-1-iodoethene. The utility of these reagents has been investigated in Suzuki-Miyaura couplings with a range of potassium trifluoroborate coupling partners, with the scope of successful couplings proving wide. Deiodinated species appeared as significant side products, but a solvent change from iso-PrOH to tert-BuOH suppressed the pathway to these species and improved coupling yields.
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Journal Details
This article was published in the following journal.
Name: The Journal of organic chemistry
ISSN: 1520-6904
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22769401
- DOI: http://dx.doi.org/10.1021/jo3011705
Medical and Biotech [MESH] Definitions
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A fluorinated cytosine analog that is used as an antifungal agent.
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