Metastin levels in pregnancies complicated by pre-eclampsia and their relation with disease severity.
Summary of "Metastin levels in pregnancies complicated by pre-eclampsia and their relation with disease severity."
Abstract Aims: To evaluate the role of metastin levels in the pathophysiology of pre-eclampsia and determine whether there is a relationship between the severity of the disease and Doppler velocimetry measurements. Methods: This cross-sectional study included 89 pregnant women (50 healthy normotensive pregnant women, 15 patients with mild pre-eclampsia, 24 patients with severe pre-eclampsia) at the third trimester of pregnancy. The maternal levels of plasma metastin were determined by enzyme-linked immunosorbent assay. The umbilical artery and uterine artery blood flow velocities were measured by transabdominal color and pulsed Doppler ultrasound. Results: Plasma metastin levels were lower in patients with pre-eclampsia than they were in the normotensive pregnant women. Four patients with mild pre-eclampsia and seven patients with severe pre-eclampsia had abnormal Doppler velocimetry results. Metastin levels of preeclamptic patients with abnormal Doppler velocimetry results were significantly lower than those in patients with normal Doppler velocimetry results. Plasma metastin levels were negatively correlated with proteinuria in 24 hours and mean arterial pressure in cases of pre-eclampsia. Conclusions: The findings suggest that decreased maternal concentrations of plasma metastin may be involved in the pathogenesis of pre-eclampsia. Plasma metastin levels may be useful in the assessment of the severity of pre-eclampsia. However, further trials are needed to clarify the role of metastin in pre-eclampsia.
Affiliation
Yuzuncu Yil University Faculty of Medicine, Department of Obstetrics and Gynecology, Van, Turkey.
Journal Details
This article was published in the following journal.
Name: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the
ISSN: 1476-4954
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22769053
- DOI: http://dx.doi.org/10.3109/14767058.2012.708369
Medical and Biotech [MESH] Definitions
Eclampsia
Onset of HYPERREFLEXIA; SEIZURES; or COMA in a previously diagnosed pre-eclamptic patient (PRE-ECLAMPSIA).
Pre-eclampsia
A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.
Magnesium Sulfate
A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083)
Hellp Syndrome
A syndrome of HEMOLYSIS, elevated liver ENZYMES, and low blood platelets count (THROMBOCYTOPENIA). HELLP syndrome is observed in pregnant women with PRE-ECLAMPSIA or ECLAMPSIA who also exhibit LIVER damage and abnormalities in BLOOD COAGULATION.
Beta-thromboglobulin
A platelet-specific protein which is released when platelets aggregate. Elevated plasma levels have been reported after deep venous thrombosis, pre-eclampsia, myocardial infarction with mural thrombosis, and myeloproliferative disorders. Measurement of beta-thromboglobulin in biological fluids by radioimmunoassay is used for the diagnosis and assessment of progress of thromboembolic disorders.
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