Detection of phase I IgG antibodies to Coxiella burnetii with EIA as a screening test for blood donations.

23:32 EDT 16th September 2014 | BioPortfolio

Summary of "Detection of phase I IgG antibodies to Coxiella burnetii with EIA as a screening test for blood donations."

The presence of a high phase I IgG antibody titre may indicate chronic infection and a risk for the transmission of Coxiella burnetii through blood transfusion. The outbreak of Q fever in the Netherlands allowed for the comparison of an enzyme immunoassay (EIA) with the reference immunofluorescence assay (IFA) in a large group of individuals one year after acute Q fever. EIA is 100 % sensitive in detecting high (≥1:1,024) phase I IgG antibody titres. The cost of screening with EIA and confirming all EIA-positive results with IFA is much lower than screening all donations with IFA. This should be taken into account in cost-effectiveness analyses of screening programmes.

Affiliation

Centre for Infectious Disease Control, National Institute for Public Health and the Environment, A. van Leeuwenhoeklaan 9, P.O. Box 1, 3720 BA, Bilthoven, The Netherlands, wim.van.der.hoek@rivm.nl.

Journal Details

This article was published in the following journal.

Name: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Micro
ISSN: 1435-4373
Pages:

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