Spectroscopic and Calorimetric Evaluation of Chemically Induced Protein Denaturation in HuH-7 Liver Cancer Cells and Impact on Cell Survival.
Summary of "Spectroscopic and Calorimetric Evaluation of Chemically Induced Protein Denaturation in HuH-7 Liver Cancer Cells and Impact on Cell Survival."
Treatment of solid tumors such as hepatocellular carcinoma (HCC) is challenging. Surgery, either resection or transplantation, is generally the best option as such tumors do not respond well to intravenous chemotherapy (1). Unfortunately, few patients qualify for surgery and there is often considerable morbidity from such major surgical procedures. This leaves a large cohort of patients that are treated by less invasive methods, such as thermal ablation and transarterial embolization (2). Historically, chemical ablation has played a significant role in cancer treatments, particularly ultrasound-guided injection of either ethanol or 50% acetic acid, (3). However, systemic toxicity limits the dose and there is difficulty in predicting the distribution of the injected agent. These issues have hampered the clinical use of these methods (4, 5). The dose limitation imposed by the systemic toxicity of the agents often results in multiple repeated treatment sessions (6).
Affiliation
Department of Radiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. cress013@umn.edu.
Journal Details
This article was published in the following journal.
Name: Technology in cancer research & treatment
ISSN: 1533-0338
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22775334
- DOI: http://dx.doi.org/
Medical and Biotech [MESH] Definitions
Cervical Ripening
A change in the CERVIX UTERI with respect to its readiness to relax. The cervix normally becomes softer, more flexible, more distensible, and shorter in the final weeks of PREGNANCY. These cervical changes can also be chemically induced (LABOR, INDUCED).
Protein Renaturation
The reconstitution of a protein's activity following denaturation.
Liver Cirrhosis, Experimental
Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.
Drug-induced Liver Injury
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.
Liver Neoplasms, Experimental
Experimentally induced tumors of the LIVER.
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