Effect of Hyperbaric Oxygen on Vibrio vulnificus and Its Infection.
Summary of "Effect of Hyperbaric Oxygen on Vibrio vulnificus and Its Infection."
Vibrio vulnificus is a bacterium known to cause fatal necrotizing soft tissue infection in humans. Here, we describe a remarkable therapeutic effect of hyperbaric oxygen (HBO) on V. vulnificus infection provoked by its injection into mouse footpads. HBO was also shown to be bactericidal to this bacterium in vitro as well as in the infected tissue. The bactericidal activity of HBO was shown to be due to reactive oxygen species (ROS), and the efficacy of HBO on V. vulnificus infection was accounted for by the high sensitivity of this bacterium to ROS. Besides being somewhat weak in ROS-inactivating enzyme activities, this bacterium was unusually sensitive also to UV and other DNA-damaging agents. It seems likely that the sensitivity of V. vulnificus to HBO is mainly due to its low ability to repair oxidative damage to DNA. These findings seemed to encourage the clinical application of HBO against fatal V. vulnificus infection in humans.
Affiliation
Department of Bacteriology, Department of Surgery and Oncology, Graduate School of Medical Sciences, Department of Oral Health, Growth and Development, Division of Oral Infectious Diseases and Immunology, Graduate School of Dental Science, Kyushu Universi
Journal Details
This article was published in the following journal.
Name: Microbiology and immunology
ISSN: 1348-0421
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22775062
- DOI: http://dx.doi.org/10.1111/j.1348-0421.2012.00491.x
Medical and Biotech [MESH] Definitions
Vibrio Vulnificus
A species of halophilic bacteria in the genus VIBRIO, which lives in warm SEAWATER. It can cause infections in those who eat raw contaminated seafood or have open wounds exposed to seawater.
Vibrio Cholerae Non-o1
A strain of the VIBRIO CHOLERAE bacteria belonging to serogroup non-O1, infecting humans and other PRIMATES. It is related to VIBRIO CHOLERAE O1, but causes a disease less severe than CHOLERA. Eating raw shellfish contaminated with the bacteria results in GASTROENTERITIS.
Hyperbaric Oxygenation
The therapeutic intermittent administration of oxygen in a chamber at greater than sea-level atmospheric pressures (three atmospheres). It is considered effective treatment for air and gas embolisms, smoke inhalation, acute carbon monoxide poisoning, caisson disease, clostridial gangrene, etc. (From Segen, Dictionary of Modern Medicine, 1992). The list of treatment modalities includes stroke.
Vibrio Mimicus
A species of gram-negative bacteria in the genus VIBRIO, isolated from SHELLFISH, as well as from human diarrheal stools and ear infections.
Vibrio Salmonicida
A species of gram-negative bacteria in the genus VIBRIO, the causative agent of cold water vibriosis, a HEMORRHAGIC SEPTICEMIA of ATLANTIC SALMON.
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