Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas.
Summary of "Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas."
No Summary Available
Affiliation
Laboratório de Endocrinologia Celular e Molecular (LIM-25), Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
Journal Details
This article was published in the following journal.
Name: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasilei
ISSN: 1414-431X
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22782554
- DOI: http://dx.doi.org/
Medical and Biotech [MESH] Definitions
Pituitary Neoplasms
Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
Mutagenesis, Insertional
Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.
Proto-oncogene Proteins C-fes
Proto-oncogene proteins fes are protein-tyrosine kinases with a central SH2 DOMAIN. It has been implicated in SIGNAL TRANSDUCTION PATHWAYS for CELL DIFFERENTIATION of a variety of cell types including MYELOID PROGENITOR CELLS. Fes proto-oncogene proteins also bind TUBULIN and promote MICROTUBULE assembly.
Proto-oncogene Protein C-ets-1
An ets proto-oncogene expressed primarily in adult LYMPHOID TISSUE; BRAIN; and VASCULAR ENDOTHELIAL CELLS.
Proto-oncogene Proteins C-cbl
Proto-oncogene proteins that negatively regulate RECEPTOR PROTEIN-TYROSINE KINASE signaling. It is a UBIQUITIN-PROTEIN LIGASE and the cellular homologue of ONCOGENE PROTEIN V-CBL.
PubMed Articles
AIP Mutation in Pituitary Adenomas.
To the Editor: Chahal et al. (Jan. 6 issue)(1) describe four families with familial isolated pituitary adenomas who had the same mutation as an 18th-century giant.(2) They conclude that the old theory...
AIP Mutation in Pituitary Adenomas.
To the Editor: Chahal et al. (Jan. 6 issue)(1) describe four families with familial isolated pituitary adenomas who had the same mutation as an 18th-century giant.(2) They conclude that the old theory...
Downregulation of HMGA-targeting microRNAs has a critical role in human pituitary tumorigenesis.
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