Preview: angew. Chem. Int. Ed. 30/2012.
Summary of "Preview: angew. Chem. Int. Ed. 30/2012."
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This article was published in the following journal.
Name: Angewandte Chemie (International ed. in English)
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22782927
- DOI: http://dx.doi.org/10.1002/anie.201290055
Medical and Biotech [MESH] Definitions
A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)
Salts or esters of carbamic acid, H2NC(=O)OH, or of N-substituted carbamic acids: R2NC(=O)OR', (R' = hydrocarbyl or a cation). The esters are often called URETHANE or urethan, a usage that is strictly correct only for the ethyl esters. (From IUPAC [Internet]. International Union Of Pure And Applied Chemistry; c1995 [updated 2004 Jan 9; cited 2004 May 3]. Available from http://www.chem.qmul.ac.uk/iupac/class/oneN.html#35/).
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