Mesenchymal stem cells and rheumatism : State of the art.
Summary of "Mesenchymal stem cells and rheumatism : State of the art."
Mesenchymal stem cells (MSC) are multipotent. They are able to regenerate tissue damage and, in parallel, inhibit inflammation and fibrosis. As they are non-immunogenic, MSCs can be safely transplanted using autologous and allogeneic procedures: an option for refractory connective tissue diseases and osteoarthritis.
Affiliation
Hôpital Saint Antoine et Université Pierre et Marie Curie, 184 rue du Faubourg Saint-Antoine, 75012, Paris, Frankreich, jan.voswinkel@sat.aphp.fr.
Journal Details
This article was published in the following journal.
Name: Zeitschrift fur Rheumatologie
ISSN: 1435-1250
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22825552
- DOI: http://dx.doi.org/10.1007/s00393-011-0950-z
Medical and Biotech [MESH] Definitions
Mesenchymal Stem Cell Transplantation
Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).
Mesenchymal Stem Cells
Cells that can develop into distinct mesenchymal tissue such as BONE; TENDONS; MUSCLES; ADIPOSE TISSUE; CARTILAGE; NERVE TISSUE; and BLOOD and BLOOD VESSELS.
Induced Pluripotent Stem Cells
Cells from adult organisms that have been reprogrammed into a pluripotential state similar to that of EMBRYONIC STEM CELLS.
Multipotent Stem Cells
Specialized stem cells that are committed to give rise to cells that have a particular function; examples are MYOBLASTS; MYELOID PROGENITOR CELLS; and skin stem cells. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from: http://www.nih.gov/news/stemcell/primer.htm)
Stem Cell Niche
A particular zone of tissue composed of a specialized microenvironment where stem cells are retained in a undifferentiated, self-renewable state.
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