Enhanced Expression of Peroxisome Proliferate-activated Receptor Gamma (PPAR-γ) in Advanced Prostate Cancer.
Summary of "Enhanced Expression of Peroxisome Proliferate-activated Receptor Gamma (PPAR-γ) in Advanced Prostate Cancer."
Recent studies have underlined the role of nuclear receptors in the involvement of prostate cancer signalling pathways.
Affiliation
Department of Urology, University of Erlangen, 91054 Erlangen, Germany. bernhard.walter@uk-erlangen.de.
Journal Details
This article was published in the following journal.
Name: Anticancer research
ISSN: 1791-7530
Pages: 3479-83
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22843934
- DOI: http://dx.doi.org/
Medical and Biotech [MESH] Definitions
Thiazolidinediones
THIAZOLES with two keto oxygens. Members are insulin-sensitizing agents which overcome INSULIN RESISTANCE by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma).
Peroxisome Proliferator-activated Receptors
TRANSCRIPTION FACTORS that are activated by ligands and heterodimerize with RETINOID X RECEPTORS and bind to peroxisome proliferator response elements in the promoter regions of target genes.
Retinoid X Receptor Gamma
A nuclear transcription factor. Heterodimerization with PPAR ALPHA is important to metabolism of LIPIDS.
Ppar Alpha
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.
Retinoid X Receptor Alpha
A nuclear transcription factor. Heterodimerization with PPAR GAMMA is important in regulation of GLUCOSE metabolism and CELL GROWTH PROCESSES.
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