Dietary selenium and selenoprotein function.
Summary of "Dietary selenium and selenoprotein function."
Selenium is a trace mineral and an essential nutrient in the human diet. Selenium is found in soil and water and consequently enters the food chain through the root ways of plants and aquatic organisms. Some areas of the world are low in soil selenium resulting in a selenium deficient population and the appearance of an associated heart disease and bone disorders that can be corrected with dietary selenium. Indeed the requirement for dietary selenium was established by these observations and while selenium deficiency is rare in the West, patients requiring long-term intravenous feedings have also show heart disease associated with a deficiency of selenium in the feeding fluids. Subsequently, it has been established that dietary selenium can improve a wide range of human health conditions even in areas with soil replete in selenium.
Affiliation
Department of Biology and Environmental Studies Program, Adelphi University, Garden City, NY, U.S.A.
Journal Details
This article was published in the following journal.
Name: Medical science monitor : international medical journal of experimental and clinical research
ISSN: 1643-3750
Pages: RA127-132
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22847213
- DOI: http://dx.doi.org/
Medical and Biotech [MESH] Definitions
Selenoprotein P
An extracellular selenoprotein that contains most of the SELENIUM in PLASMA. Selenoprotein P functions as an antioxidant and appears to transport selenium from the LIVER to peripheral tissues.
Selenious Acid
A selenium compound used as a source of SELENIUM, especially for patients that develop selenium deficiency following prolonged PARENTERAL NUTRITION.
Selenium Radioisotopes
Unstable isotopes of selenium that decay or disintegrate emitting radiation. Se atoms with atomic weights 70-73, 75, 79, 81, and 83-85 are radioactive selenium isotopes.
Selenium-binding Proteins
A group of proteins that covalently attach to selenium or SELENIUM-containing compounds.
Phosphorus, Dietary
Phosphorus used in foods or obtained from food. This element is a major intracellular component which plays an important role in many biochemical pathways relating to normal physiological functions. High concentrations of dietary phosphorus can cause nephrocalcinosis which is associated with impaired kidney function. Low concentrations of dietary phosphorus cause an increase in calcitriol in the blood and osteoporosis.
PubMed Articles
Dietary Selenium Affects Selenoprotein W Gene Expression in the Liver of Chicken.
As selenium in the form of "Selenoprotein W (SelW)" is essential for the maintenance of normal liver function, the expression of SelW liver depends on the level of selenium supplied with the diet. Whe...
Relevance of selenoprotein transcripts for selenium status in humans.
The most commonly used methods for assessing the selenium (Se) status in humans involve analysis of Se concentration, selenoprotein activity, and concentration in the blood and its compartments. Recen...
Selenium effect on selenoprotein transcriptome in chondrocytes.
Selenium is an essential micronutrient and exerts its biological functions predominantly through selenoproteins. Selenium deficiency is associated with cartilage function. This study demonstrated that...
Selenium Regulates Gene Expression of Selenoprotein W in Chicken Gastrointestinal Tract.
Selenoprotein W (SelW) is an existing form of selenium (Se). Se influences the levels of SelW in mammals. However, little is known about the pattern of SelW expression in the gastrointestinal tract ti...
A prospective study of dietary selenium intake and risk of type 2 diabetes.
ABSTRACT: BACKGROUND: Growing evidence raises concern about possible associations of high selenium exposure with diabetes in selenium-replete populations such as the US. In countries with lower seleni...
Clinical Trials
Optimization of Selenoprotein P in Chinese Subjects
The purpose of this study is to determine the amount of selenium as selenomethionine that is required to optimize selenoprotein P in selenium-deficient Chinese subjects
The aim of the study is to investigate the relationship between dose and form of selenium on immune function, and to identify functional markers of selenium status.
Supplemental Selenium and Vitamin E and Pulmonary Function
To test whether anti-oxidant supplementation with selenium and/or vitamin E affects pulmonary function.
Selenium Supplementation of Patients With Cirrhosis
This study is being conducted to determine if patients with cirrhosis (liver disease) are selenium deficient. The effect of supplementation with two chemical forms of selenium on plasma se...
Selenium Supplementation of Patients With Cirrhosis
The purpose of this study is to determine whether patients with liver cirrhosis can improve their selenium nutritional status by taking supplemental selenium.
