Pancreas transplantation from donors after circulatory death from the United kingdom.
Summary of "Pancreas transplantation from donors after circulatory death from the United kingdom."
This study reports the comparative short-term results of pancreas transplantation from donors after circulatory death (DCD) (Maastricht III & IV), and pancreases from brainstem deceased donors (DBD). Between January 2006 and December 2010, 1009 pancreas transplants were performed in the United Kingdom, with 134 grafts from DCD and 875 from DBD. DCD grafts had no premortem pharmacological interventions performed. One-year pancreas and patient survival was similar between DCD and DBD, with pancreas graft survival significantly better in the DCD cohort if performed as an SPK. Early graft loss due to thrombosis (8% vs. 4%) was mainly responsible for early graft loss in the DCD cohort. These results from donors with broader acceptance criteria in age, body mass index, premortem interventions, etc. suggest that DCD pancreas grafts may have a larger application potential than previously recognized.
Affiliation
Oxford Transplant Centre, Churchill Hospital, Roosevelt Drive, Oxford, UK Organ donation and Transplantation Directorate, NHS Blood and Transplant, Fox Den Road, Stoke Gifford, Bristol, UK Nuffield Department of Surgical Sciences, University of Oxford, Ch
Journal Details
This article was published in the following journal.
Name: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Tr
ISSN: 1600-6143
Pages: 2150-6
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22845910
- DOI: http://dx.doi.org/10.1111/j.1600-6143.2012.04075.x
Medical and Biotech [MESH] Definitions
Pancreas Transplantation
The transference of a pancreas from one human or animal to another.
Tissue And Organ Procurement
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
Tissue And Organ Harvesting
The procedure of removing TISSUES, organs, or specimens from DONORS for reuse, such as TRANSPLANTATION.
Transplantation Conditioning
Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.
Tissue Donors
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
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