Changes in matrix metalloproteinases and their inhibitors in kidney transplant recipients.
Summary of "Changes in matrix metalloproteinases and their inhibitors in kidney transplant recipients."
Chronic allograft nephropathy remains one of the main causes of late graft loss after kidney transplant owing to multifactorial development of kidney scarring. Chronic allograft nephropathy is characterised by an excess accumulation of extracellular matrix. A key system regulating extracellular matrix homeostasis are matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases. This study sought to determine if a change in the matrix metalloproteinases/tissue inhibitors of matrix metalloproteinases system contributes to chronic allograft nephropathy-associated progressive kidney scarring.
Affiliation
From the Department of Renal Medicine, Royal Preston Hospital, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, United Kingdom.
Journal Details
This article was published in the following journal.
Name: Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
ISSN: 2146-8427
Pages: 332-43
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22845765
- DOI: http://dx.doi.org/
Medical and Biotech [MESH] Definitions
Matrix Metalloproteinases, Membrane-associated
Matrix metalloproteinases that are associated with the CELL MEMBRANE, either through transmembrane domains or GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORS. Membrane-type matrix metalloproteinases may act within the pericellular environment to influence the process of CELL MIGRATION.
Matrix Metalloproteinases, Secreted
A subclass of matrix metalloproteinases that are secreted into the pericellular space.
Matrix Metalloproteinase 16
A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the proteolytic action of PROPROTEIN CONVERTASES. Matrix metalloproteinase 16 plays a direct role in the cleavage of proteins in the pericellular environment. In addition it can function indirectly by enzymatically activating the proprotein form of other MATRIX METALLOPROTEINASES such as the zymogen of MATRIX METALLOPROTEINASE 2.
Matrix Metalloproteinases
A family of zinc-dependent metalloendopeptidases that are involved in the degradation of EXTRACELLULAR MATRIX components. EC 3.4.24.-.
Matrix Metalloproteinase 7
The smallest member of the MATRIX METALLOPROTEINASES. It plays a role in tumor progression.
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