Palmar pits associated with the nevoid basal cell carcinoma syndrome.
Summary of "Palmar pits associated with the nevoid basal cell carcinoma syndrome."
No Summary Available
Affiliation
Departments of Pathology and Dermatology, University of California, San Francisco, San Francisco, CA.
Journal Details
This article was published in the following journal.
Name: Journal of cutaneous pathology
ISSN: 1600-0560
Pages: 736-8
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22845656
- DOI: http://dx.doi.org/10.1111/j.1600-0560.2012.01984.x
Medical and Biotech [MESH] Definitions
Coated Pits, Cell-membrane
Specialized regions of the cell membrane composed of pits coated with a bristle covering made of the protein CLATHRIN. These pits are the entry route for macromolecules bound by cell surface receptors. The pits are then internalized into the cytoplasm to form the COATED VESICLES.
Carcinoma, Merkel Cell
A carcinoma arising from MERKEL CELLS located in the basal layer of the epidermis and occurring most commonly as a primary neuroendocrine carcinoma of the skin. Merkel cells are tactile cells of neuroectodermal origin and histologically show neurosecretory granules. The skin of the head and neck are a common site of Merkel cell carcinoma, occurring generally in elderly patients. (Holland et al., Cancer Medicine, 3d ed, p1245)
Dupuytren Contracture
A fibromatosis of the palmar fascia characterized by thickening and contracture of the fibrous bands on the palmar surfaces of the hand and fingers. It arises most commonly in men between the ages of 30 and 50.
Carcinoma, Basosquamous
A skin carcinoma that histologically exhibits both basal and squamous elements. (From Dorland, 27th ed)
Carcinoma, Non-small-cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
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Palmar pits associated with the nevoid basal cell carcinoma syndrome.
Frameshift mutation in the PTCH2 gene can cause nevoid basal cell carcinoma syndrome.
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