Evaluation of antidiabetic potential of oyster mushroom (Pleurotus ostreatus) in alloxan-induced diabetic mice.
Summary of "Evaluation of antidiabetic potential of oyster mushroom (Pleurotus ostreatus) in alloxan-induced diabetic mice."
Objectives: To study the antidiabetic activity of Pleurotus ostreatus in normal and alloxan-induced diabetic mice. Materials and methods: Ethanolic extract of fruiting bodies of P. ostreatus was tested for their antidiabetic activity. BALB/C mice (25-30 g) were divided into four groups of six animals each normal control mice, diabetic control mice, diabetic mice posttreated with standard drug glibenclamide and diabetic mice treated with P. ostreatus ethanolic extract. Blood glucose level, biochemical parameters such as serum total cholesterol, LDL, HDL, VLDL, triglyceride creatinine, urea, and Serum glutamate oxaloacetate transaminase and Serum glutamate pyruvate transaminase were studied in alloxan-induced diabetic mice after 15 days of treatment. Results: Animals treated with the ethanolic extract of P. ostreatus showed a significant decrease in serum glucose level (p < 0.01). The posttreatment with P. ostreatus extract reduced serum cholesterol, triglyceride and LDL-cholesterol. The serum HDL cholesterol was significantly increased in posttreated groups. The serum creatinine, urea levels were significantly reduced in posttreated group, whereas the decrease in the body weight was arrested by administration of P. ostreatus extract to the animals. Discussion and conclusion: The consumption of P. ostreatus produced a significant hypoglycemic effect in diabetic mice and it is capable of improving hyperlipidemia and the impaired kidney functions in alloxan-induced diabetic mice. Thus, indicating that the ethanolic extract of P. ostreatus could be added in the list of medicinal preparations beneficial in diabetes mellitus.
Affiliation
Department of Biotechnology, Karunya University , Coimbatore, Tamil Nadu , India.
Journal Details
This article was published in the following journal.
Name: Immunopharmacology and immunotoxicology
ISSN: 1532-2513
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22867521
- DOI: http://dx.doi.org/10.3109/08923973.2012.710635
Medical and Biotech [MESH] Definitions
Pleurotus
A genus of basidiomycetous fungi, family POLYPORACEAE, order POLYPORALES, that grows on logs or tree stumps in shelflike layers. The species P. ostreatus, the oyster mushroom, is a choice edible species and is the most frequently encountered member of the genus in eastern North America. (Alexopoulos et al., Introductory Mycology, 4th ed, p531)
Agaricus
A basidiomycetous fungal genus of the family Agaricaceae, order Agaricales, which includes the field mushroom (A. campestris) and the commercial mushroom (A. bisporus).
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Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
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Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.
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