Mucoadhesive nanoliposomal formulation for vaginal delivery of an antifungal.
Summary of "Mucoadhesive nanoliposomal formulation for vaginal delivery of an antifungal."
Context: Ciclopirox olamine (CPO) is indicated in the treatment of vaginal fungal infections. The frequent and large dosing of available vaginal CPO creams gives rise to poor compliance amongst females. In such a situation a delivery system capable of providing sustained release of CPO is warranted and can be realized through incorporation of its liposomal formulation into a mucoadhesive gel base. The liposomal formulation would offer sustained release whereas mucoadhesive gel would prolong the contact with vaginal wall; thus avoiding frequent and large dosing. Objective: The present study aimed at investigating mucoadhesive liposomal CPO gel for vaginal use. Method: The study embarked on evaluating liposomal CPO and its Carbopol 974(®)P gel for stability at vaginal pH, release profile, rheological characteristics, mucoadhesive behavior and finally antifungal activity. Results: The results revealed that CPO liposomes were stable at vaginal pH; its Carbopol gel released 58.75 ± 6.4% of CPO at the end of 24 h which suggested sustained release. Rheology via viscometric, oscillatory stress sweep and oscillatory frequency sweep testing of the gel, studied at different temperatures and under different dilutions with vaginal fluid simulant testified pseudoplastic behavior of the gel. It also pointed towards the predominance of elastic behavior of the gel at all the dilutions. The gel exhibited good mucoadhesivity to sheep vaginal tissue. Furthermore, CPO entrapped in liposome too displayed antifungal activity. Conclusion: The study undertaken recommended Carbopol 974(®)P gel loaded with CPO liposomes as a potential delivery system for treatment of fungal vaginal infections.
Affiliation
Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University , Erandwane, Pune, Maharashtra , India.
Journal Details
This article was published in the following journal.
Name: Drug development and industrial pharmacy
ISSN: 1520-5762
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22866766
- DOI: http://dx.doi.org/10.3109/03639045.2012.707204
Medical and Biotech [MESH] Definitions
Episiotomy
An incision of the posterior vaginal wall and a portion of the pudenda which enlarges the vaginal introitus to facilitate delivery and prevent lacerations.
Vaginal Birth After Cesarean
Delivery of an infant through the vagina in a female who has had a prior cesarean section.
Cephalopelvic Disproportion
A condition in which the HEAD of the FETUS is larger than the mother's PELVIS through which the fetal head must pass during a vaginal delivery.
Vaginal Smears
Collection of pooled secretions of the posterior vaginal fornix for cytologic examination.
Tropolone
A seven-membered aromatic ring compound. It is structurally related to a number of naturally occurring antifungal compounds (ANTIFUNGAL AGENTS).
PubMed Articles
Therapeutic Potential of Mucoadhesive Drug Delivery Systems - An Updated Patent Review.
There has been a burgeoning interest among the research scientists to associate the drugs to polymeric particulate systems due to the propensity of these systems to interact with the mucosal surface....
Targeting of survivin by nanoliposomal ceramide induces complete remission in NK-LGL leukemia.
The NK type of aggressive LGL leukemia is a fatal illness which pursues a rapid clinical course. There are no effective therapies for this illness and pathogenetic mechanisms remain undefined. Here we...
Formulation of mucoadhesive vaginal hydrogels insensitive to dilution with vaginal fluids.
The main objective of this work was to design thermosensitive and mucoadhesive vaginal hydrogels able to keep their rheological and mucoadhesive properties after dilution with vaginal fluids. Formulat...
Abstract Context: Mucoadhesive buccal films containing three layers (mucoadhesive layer, nanosuspension containing layer and backing membrane) were incorporated with carvedilol nanosuspension. Objecti...
Rheological and mechanical properties of poloxamer mixtures as a mucoadhesive gel base.
This study described the thermosensitive formulations composed of poloxamer mixtures for use as drug delivery platform via mucosal route. It also characterized the poloxamer mixtures' rheological, mec...
Clinical Trials
Epidural Morphine Following Vaginal Delivery
The investigators believe that pain management following a vaginal delivery can be improved. Many women receive epidural medication during labor and delivery, and the investigators felt...
EPICc:Anal Incontinence After Delivery. Secondary Prevention With Caesarean Section.
Anal incontinence is frequent and treatment is difficult. One of the most important reason is traumatic delivery. 10 % of women develop anal incontinence after first delivery. This inciden...
The Association Between Delivery Method and Maternal Rehospitalization
Hypothesis: The rates of rehospitalization after cesarean section are significantly higher than those following spontaneous vaginal delivery and are due mainly to late bleeding and less to...
Safety and Efficacy Study of Misoprostol Vaginal Insert for Induction of Labour
The primary objective of the study was assessment of the efficacy of four dose reservoirs (25 mcg, 50 mcg, 100 mcg, 200 mcg) of intravaginal controlled release misoprostol administered for...
Uptake of the Antifungal Miconazole and Effect on Estrogen Metabolizing Enzymes in Humans
The purpose of this study, is to study the uptake of the pharmaceutical antifungal miconazole when used as a vaginal suppository in young women. The investigators want to know if the uptak...
