Administration of donepezil does not rescue galanin-induced spatial learning deficits.
Summary of "Administration of donepezil does not rescue galanin-induced spatial learning deficits."
Abstract The neuropeptide galanin inhibits the evoked release of several neurotransmitters, including acetylcholine, and modulates adenylate cyclase activity. Galanin has also been established to impair various forms of learning and memory in rodents. However, whether galanin produces learning deficits by inhibiting cholinergic activity or decreasing adenylate cyclase function has not been clearly established. The current study investigated if donepezil, an acetylcholinesterase inhibitor utilized in Alzheimer's disease, could rescue galanin-induced Morris water task deficits in rats. The results demonstrated that donepezil did not alter the previously established deficits induced by galanin. These findings suggest that galanin-mediated spatial learning deficits may be unrelated to its modulation of the cholinergic system.
1Behavioral Neuroscience Laboratory, University of Nevada , Las Vegas, Las Vegas, NV.
This article was published in the following journal.
Name: The International journal of neuroscience
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22897394
- DOI: http://dx.doi.org/10.3109/00207454.2012.721411
Medical and Biotech [MESH] Definitions
A family of G-protein-coupled receptors that are specific for GALANIN and galanin peptides. They are generally considered to be coupled to the GI, INHIBITORY G-PROTEIN to meditate the neurological effects of galanin. Several subtypes of galanin receptors occur with differing specificities for the full length galanin, galanin peptide fragments, and galanin-like peptide.
A neuropeptide that is highly homologous to GALANIN. It is produced by proteolytic processing of a larger protein that is unrelated to prepro-galanin and preferentially binds to GALANIN-2 RECEPTOR.
Receptor, Galanin, Type 2
A galanin receptor subtype with broad specificity for full length GALANIN, galanin peptide fragments and GALANIN-LIKE PEPTIDE.
Receptor, Galanin, Type 3
A galanin receptor subtype with high affinity for GALANIN-LIKE PEPTIDE and low affinity for full length GALANIN and galanin peptide fragments.
A neuropeptide of 29-30 amino acids depending on the species. Galanin is widely distributed throughout the BRAIN; SPINAL CORD; and INTESTINES. There are various subtypes of GALANIN RECEPTORS implicating roles of galanin in regulating FOOD INTAKE; pain perception; memory; and other neuroendocrine functions.
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