Administration of donepezil does not rescue galanin-induced spatial learning deficits.
Summary of "Administration of donepezil does not rescue galanin-induced spatial learning deficits."
Abstract The neuropeptide galanin inhibits the evoked release of several neurotransmitters, including acetylcholine, and modulates adenylate cyclase activity. Galanin has also been established to impair various forms of learning and memory in rodents. However, whether galanin produces learning deficits by inhibiting cholinergic activity or decreasing adenylate cyclase function has not been clearly established. The current study investigated if donepezil, an acetylcholinesterase inhibitor utilized in Alzheimer's disease, could rescue galanin-induced Morris water task deficits in rats. The results demonstrated that donepezil did not alter the previously established deficits induced by galanin. These findings suggest that galanin-mediated spatial learning deficits may be unrelated to its modulation of the cholinergic system.
Affiliation
1Behavioral Neuroscience Laboratory, University of Nevada , Las Vegas, Las Vegas, NV.
Journal Details
This article was published in the following journal.
Name: The International journal of neuroscience
ISSN: 1563-5279
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22897394
- DOI: http://dx.doi.org/10.3109/00207454.2012.721411
Medical and Biotech [MESH] Definitions
Receptors, Galanin
A family of G-protein-coupled receptors that are specific for GALANIN and galanin peptides. They are generally considered to be coupled to the GI, INHIBITORY G-PROTEIN to meditate the neurological effects of galanin. Several subtypes of galanin receptors occur with differing specificities for the full length galanin, galanin peptide fragments, and galanin-like peptide.
Galanin-like Peptide
A neuropeptide that is highly homologous to GALANIN. It is produced by proteolytic processing of a larger protein that is unrelated to prepro-galanin and preferentially binds to GALANIN-2 RECEPTOR.
Receptor, Galanin, Type 2
A galanin receptor subtype with broad specificity for full length GALANIN, galanin peptide fragments and GALANIN-LIKE PEPTIDE.
Receptor, Galanin, Type 3
A galanin receptor subtype with high affinity for GALANIN-LIKE PEPTIDE and low affinity for full length GALANIN and galanin peptide fragments.
Galanin
A neuropeptide of 29-30 amino acids depending on the species. Galanin is widely distributed throughout the BRAIN; SPINAL CORD; and INTESTINES. There are various subtypes of GALANIN RECEPTORS implicating roles of galanin in regulating FOOD INTAKE; pain perception; memory; and other neuroendocrine functions.
PubMed Articles
The effects of yokukansan and donepezil on learning disturbance and aggressiveness were examined in amyloid beta protein (Abeta)-injected mice. Intellicage tests showed that both yokukansan and donepe...
Antinociceptive effects of galanin in the nucleus accumbens of rats.
It has been demonstrated that galanin plays important roles in the modulation of nociceptive information in rats. The present study is performed to investigate the regulating role of galanin in nocice...
The effects of galanin on neuropathic pain in streptozotocin-induced diabetic rats.
Diabetic neuropathy is a common complication associated with diabetes and is frequently painful. However, mechanisms responsible for diabetic neuropathic pain are still unclear. Experimental evidence...
RATIONALE: Use of cross-species neuropsychological paradigms such as visual-spatial paired associate learning (PAL) may allow for a better understanding of underlying neural substrates of memory. Such...
The effects of the neurotoxin DSP4 on spatial learning and memory in Wistar rats.
The aim of the present study was to investigate the effect of DSP4-induced noradrenaline depletion on learning and memory in a spatial memory paradigm (holeboard). Since Harro et al. Brain Res 976:209...
Clinical Trials
Pharmacokinetic Interaction Between AZD3480 and Donepezil
The aims of this study are to 1) examine the effects of AZD3480 and donepezil on the blood concentrations of each other and 2) assess the safety and tolerability of the combined administra...
The Effect of Donepezil on Sedation and Other Symptoms
Primary Objective: 1. To determine the effectiveness of donepezil as compared to placebo for the management of opiate-induced sedation/drowsiness in patients with stable cancer pain...
The Effect of Donepezil (Aricept(Registered Trademark)) on REM Sleep in Children With Autism
This study will test whether donepezil (Aricept(Registered Trademark)), a drug that is approved by the Food and Drug Administration to treat Alzheimer's disease, can increase rapid eye mov...
A Healthy Volunteer Study to Evaluate Reversibility of Induced Impairment of Cognition
The purpose of this study is to determine if cognitive impairment induced by scopolamine is reversed using donepezil and/or AZD1446 as compared to placebo, as assessed by electroencephalog...
The purpose of this study is to determine if there is improvement or measurable change in cognition after only one month of treatment with donepezil when using a computerized test battery....
