AA genotype of IL-8 -251A/T is associated with low PaO(2) /FiO(2) in critically ill patients and with increased IL-8 expression.
Summary of "AA genotype of IL-8 -251A/T is associated with low PaO(2) /FiO(2) in critically ill patients and with increased IL-8 expression."
SUMMARY AT A
This study demonstrated that variation in the IL-8 promoter gene region was associated with increased risk of impaired oxygenation and prolonged mechanical ventilation in the critically ill patients. One possible mechanism may be because of altered IL-8 mRNA expression
Background and Objective: Interleukin-8 (IL-8) is a central chemokine in acute respiratory distress syndrome (ARDS) and the IL-8 gene contains a functional single nucleotide polymorphism (SNP) -251A/T in its promoter region.We hypothesized that IL-8 -251A/T SNP is associated with PaO(2) /FiO(2) in critically ill patients. Methods: We conducted genetic-association studies in intensive care units at academic teaching centers using a derivation septic shock cohort (VASST, n=467) and a validation post-cardiopulmonary bypass surgery cohort (CPB, n=739) of Caucasian patients. Patients in both cohorts were genotyped for IL-8 -251A/T. The primary outcome variable in both cohorts was the fraction of patients who had a PaO(2) /FiO(2) < 200. IL-8 mRNA expression was measured in genotyped lymphoblastoid cells in vitro. Results: The frequency of the patients with PaO(2) /FiO(2) <200 was significant greater in patients who had the AA genotype of -251A/T than patients who had the AT or TT genotypes in both VASST (AA =60.8% vs. AT and TT =53.8% and 48.0%, p=0.038) and the CPB cohort (AA =37.0% vs. AT and TT =27.0% and 26.0%, p=0.039). Patients having the AA genotype had a higher probability to remaining on mechanical ventilation (p=0.047) in the first 14 days. Lymphoblastoid cells having the AA genotype had significantly higher IL-8 mRNA expression than cells having the AT or TT genotype (p=0.022). Conclusions: Caucasian critically ill patients who had the AA genotype of IL-8 -251A/T had an increased risk of PaO(2) /FiO(2) <200. The AA genotype was associated with greater IL-8 mRNA expression than the AT or TT genotypes. © 2012 The Authors. Respirology © 2012 Asian Pacific Society of Respirology.
University of British Columbia, Critical Care Research Laboratories, Institute for Heart+Lung Health, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6.
This article was published in the following journal.
Name: Respirology (Carlton, Vic.)
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22897124
- DOI: http://dx.doi.org/10.1111/j.1440-1843.2012.02244.x
Medical and Biotech [MESH] Definitions
An acronym for Acute Physiology and Chronic Health Evaluation, a scoring system using routinely collected data and providing an accurate, objective description for a broad range of intensive care unit admissions, measuring severity of illness in critically ill patients.
A short-acting opioid anesthetic and analgesic derivative of FENTANYL. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients.
The genetic constitution of the individual; the characterization of the genes.
Health care provided to a critically ill patient during a medical emergency or crisis.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
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