Alterations in Serum Lipid Profile Patterns in Oral Lichen Planus: A Cross-Sectional Study.
Summary of "Alterations in Serum Lipid Profile Patterns in Oral Lichen Planus: A Cross-Sectional Study."
Background: Oral lichen planus (OLP) is a chronic inflammatory disorder. Recently, a case-control study found that lichen planus was associated with dyslipidemia in a large series of patients. However, no data were presented about lipid values in patients and controls. Objectives: The aim of this study was to investigate the hypothetical association between OLP and dyslipidemia. Materials and Methods: The study included a total of 400 patients (200 with OLP and 200 controls with other oral diseases) and investigated the prevalence of dyslipidemia. The variables analyzed were age, sex, tobacco and alcohol consumption, clinical form of OLP and lipid profiles. Results: A 54% prevalence of dyslipidemia was found (58% among the OLP group and 50% in the control group). Statistically significant differences in high-density lipoprotein were found between OLP patients and the control group (p = 0.003). A logistic regression model for presence/absence of cardiovascular risk (Castelli's atherogenic index of ≥5.1 for men and ≥4.5 for women) found statistically significant differences for sex and tobacco consumption. Conclusions: The study found a higher atherogenic index amongst OLP patients.
Affiliation
Department of Oral Medicine, Faculty of Medicine and Odontology, University of Murcia, Murcia, Spain.
Journal Details
This article was published in the following journal.
Name: American journal of clinical dermatology
ISSN: 1175-0561
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22924867
- DOI: http://dx.doi.org/10.2165/11633600-000000000-00000
Medical and Biotech [MESH] Definitions
Lichen Planus, Oral
Oral lesions accompanying cutaneous lichen planus or often occurring alone. The buccal mucosa, lips, gingivae, floor of the mouth, and palate are usually affected (in a descending order of frequency). Typically, oral lesions consist of radiating white or gray, velvety, threadlike lines, arranged in a reticular pattern, at the intersection of which there may be minute, white, elevated dots or streaks (Wickham's striae). (Jablonski, Illustrated Dictionary of Dentistry)
Etretinate
An oral retinoid used in the treatment of keratotic genodermatosis, lichen planus, and psoriasis. Beneficial effects have also been claimed in the prophylaxis of epithelial neoplasia. The compound may be teratogenic.
Fatty Acids, Omega-3
A group of fatty acids, often of marine origin, which have the first unsaturated bond in the third position from the omega carbon. These fatty acids are believed to reduce serum triglycerides, prevent insulin resistance, improve lipid profile, prolong bleeding times, reduce platelet counts, and decrease platelet adhesiveness.
Lichenoid Eruptions
Conditions in which there is histological damage to the lower epidermis along with a grouped chronic inflammatory infiltrate in the papillary dermis disturbing the interface between the epidermis and dermis. LICHEN PLANUS is the prototype of all lichenoid eruptions. (From Rook et al., Textbook of Dermatology, 4th ed, p398)
Parapsoriasis
The term applied to a group of relatively uncommon inflammatory, maculopapular, scaly eruptions of unknown etiology and resistant to conventional treatment. Eruptions are both psoriatic and lichenoid in appearance, but the diseases are distinct from psoriasis, lichen planus, or other recognized dermatoses. Proposed nomenclature divides parapsoriasis into two distinct subgroups, PITYRIASIS LICHENOIDES and parapsoriasis en plaques (small- and large-plaque parapsoriasis).
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