New abietane norditerpenoid from Salvia miltiorrhiza with cytotoxic activities.
Summary of "New abietane norditerpenoid from Salvia miltiorrhiza with cytotoxic activities."
One new abietane-type norditerpenoid, named militibetin A (1), was isolated from the dry roots of Salvia miltiorrhiza, along with two known diterpenoids, yunnannin A (2) and ferruginol (3). Their structures were established by means of extensive spectroscopic analyses. In vitro, compounds 1-3 were found to show cytotoxicities against selected cancer cells, including P-388, HONE-1, and HT-29, and gave ED(50) values in the range of 2.9-5.4 μg ml(- 1).
Affiliation
a School of Pharmaceutical Science, Yantai University , Yantai , 264005 , China.
Journal Details
This article was published in the following journal.
Name: Journal of Asian natural products research
ISSN: 1477-2213
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22924543
- DOI: http://dx.doi.org/10.1080/10286020.2012.699962
Medical and Biotech [MESH] Definitions
Salvia Miltiorrhiza
A plant species which is known as an Oriental traditional medicinal plant.
Salvia Officinalis
A plant species of the Salvia genus known as a spice and medicinal plant.
Salvia
A genus in the mint family (LAMIACEAE).
Aconitine
A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM plants. It activates voltage-gated SODIUM CHANNELS. It has been used to induce arhythmias in experimental animals and it has antiinflammatory and antineuralgic properties.
Interleukin-18
A cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK CELLS and CYTOTOXIC T-LYMPHOCYTES, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.
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