Aquisiflavoside, a new nitric oxide production inhibitor from the leaves of Aquilaria sinensis.
Summary of "Aquisiflavoside, a new nitric oxide production inhibitor from the leaves of Aquilaria sinensis."
A new flavonoid glycoside, named aquisiflavoside, was isolated from the leaves of Aquilaria sinensis (Lour.) Gilg, and its structure was elucidated by spectroscopic analyses. Aquisiflavoside was evaluated for the inhibition of nitric oxide (NO) production induced by lipopolysaccharide in macrophage cell line RAW 264.7 and exhibited a potent inhibitory activity against NO production in a dose-dependent manner with an IC(50) value of 34.95 μM.
Affiliation
a State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines , School of Pharmaceutical Sciences, Peking University , Beijing , 100191 , China.
Journal Details
This article was published in the following journal.
Name: Journal of Asian natural products research
ISSN: 1477-2213
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22924533
- DOI: http://dx.doi.org/10.1080/10286020.2012.701209
Medical and Biotech [MESH] Definitions
Nitric Oxide
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Nitric Oxide Synthase
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
Nitric Oxide Synthase Type Iii
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in ENDOTHELIAL CELLS.
Nitric Oxide Synthase Type I
A CALCIUM-dependent, constitutively-expressed form of nitric oxide synthase found primarily in NERVE TISSUE.
Nitric Oxide Synthase Type Ii
A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.
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