Two new metabolites from a soil fungus Curvularia affinis strain HS-FG-196.
Summary of "Two new metabolites from a soil fungus Curvularia affinis strain HS-FG-196."
Two new metabolites, pyrenocine J (1) and pyrenochaetic acid D (2), together with two known metabolites, pyrenocine A (3) and pyrenochaetic acid A (4), were isolated from a soil fungus, Curvularia affinis strain HS-FG-196. Their structures were established by extensive spectroscopic analysis. Compound 1 showed cytotoxic activity against the human hepatic cancer cell line HepG2 with an IC(50) value of 28.5 μg/ml.
Affiliation
a College of Pharmaceutical Science, Zhejiang University of Technology , Hangzhou , 310014 , China.
Journal Details
This article was published in the following journal.
Name: Journal of Asian natural products research
ISSN: 1477-2213
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22924340
- DOI: http://dx.doi.org/10.1080/10286020.2012.713351
Medical and Biotech [MESH] Definitions
Tenuazonic Acid
3-Acetyl-5-sec-butyl-4-hydroxy-3-pyrrolin-2-one. A metabolite found in a strain of the fungus Alternaria tenuis Auct. which functions as an antibiotic with antiviral and antineoplastic properties, and may also act as a mycotoxin.
Sporothrix
A mitosporic Ophiostomataceae fungal genus, whose species Sporothrix schenckii is a well-known animal pathogen. The conidia of this soil fungus may be inhaled causing a primary lung infection, or may infect independently via skin punctures.
Carmovirus
A genus in the family TOMBUSVIRIDAE mostly found in temperate regions. Some species infecting legumes (FABACEAE) are reported from tropical areas. Most viruses are soil-borne, but some are transmitted by the fungus Olpidium radicale and others by beetles. Carnation mottle virus is the type species.
Soil Pollutants
Substances which pollute the soil. Use for soil pollutants in general or for which there is no specific heading.
Rats, Wistar
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
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