Two new metabolites from a soil fungus Curvularia affinis strain HS-FG-196.
Summary of "Two new metabolites from a soil fungus Curvularia affinis strain HS-FG-196."
Two new metabolites, pyrenocine J (1) and pyrenochaetic acid D (2), together with two known metabolites, pyrenocine A (3) and pyrenochaetic acid A (4), were isolated from a soil fungus, Curvularia affinis strain HS-FG-196. Their structures were established by extensive spectroscopic analysis. Compound 1 showed cytotoxic activity against the human hepatic cancer cell line HepG2 with an IC(50) value of 28.5 μg/ml.
a College of Pharmaceutical Science, Zhejiang University of Technology , Hangzhou , 310014 , China.
This article was published in the following journal.
Name: Journal of Asian natural products research
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22924340
- DOI: http://dx.doi.org/10.1080/10286020.2012.713351
Medical and Biotech [MESH] Definitions
3-Acetyl-5-sec-butyl-4-hydroxy-3-pyrrolin-2-one. A metabolite found in a strain of the fungus Alternaria tenuis Auct. which functions as an antibiotic with antiviral and antineoplastic properties, and may also act as a mycotoxin.
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