Comparison of the fatty acid composition of maternal blood and cord blood of mothers who delivered healthy full-term babies, preterm babies, and full-term small for gestational age infants.
Summary of "Comparison of the fatty acid composition of maternal blood and cord blood of mothers who delivered healthy full-term babies, preterm babies, and full-term small for gestational age infants."
Abstract Objective: The aim of this study was to determine and compare the fatty acid profile of maternal blood and cord blood of children born at term (group A); those born prematurely (group B); and children born with hypotrophic features (group C). Methods: The study consisted of 109 women. Fatty acid composition was determined by gas chromatography-mass spectrometry (GC/MS). Results: 29 fatty acids (FAs) were identified in the maternal blood and 33 FAs were identified in the cord blood. Significant differences in the levels of C18:3n-6 and C20:5n-3 were noted when comparing the FA composition of maternal blood samples from the three different groups (A, B and C). Seven statistical differences were detected in the cord blood. They concerned C12:0, C18:0, C18:1c, C18:3n-6, C20:0, C20:3n-6 and C20:4n-6. Conclusion: Our research has shown that the fatty acid profile of both the maternal blood and the cord blood undergoes changes in response to pregnancy duration and the presence of reduced fetal growth. Statistical differences between groups B and C compared with group A, show that the placental-fetal transport of fatty acids in group B and C infants may differ from that of group A children.
Affiliation
University of Bielsko-Biala, Faculty of Health Science, ul. Willowa 2, Bielsko-Biala, 43-309 Poland.
Journal Details
This article was published in the following journal.
Name: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the
ISSN: 1476-4954
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22928496
- DOI: http://dx.doi.org/10.3109/14767058.2012.722717
Medical and Biotech [MESH] Definitions
Fetal Blood
Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.
Maternal-fetal Exchange
Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission.
Cord Blood Stem Cell Transplantation
Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.
Postpartum Hemorrhage
Excess blood loss from uterine bleeding associated with OBSTETRIC LABOR or CHILDBIRTH. It is defined as blood loss greater than 500 ml or of the amount that adversely affects the maternal physiology, such as BLOOD PRESSURE and HEMATOCRIT. Postpartum hemorrhage is divided into two categories, immediate (within first 24 hours after birth) or delayed (after 24 hours postpartum).
Blood Safety
The degree to which the blood supply for BLOOD TRANSFUSIONS is free of harmful substances or infectious agents, and properly typed and crossmatched (BLOOD GROUPING AND CROSSMATCHING) to insure serological compatibility between BLOOD DONORS and recipients.
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