Autophagy, mitochondria and 3-nitropropionic acid joined in the same model.
Summary of "Autophagy, mitochondria and 3-nitropropionic acid joined in the same model."
Huntington's disease (HD) is a neurodegenerative disorder caused by a mutation in the gene encoding the Huntingtin protein. Although the precise mechanism by which neuronal degeneration occurs is still unclear, several elements are important to its development: 1) altered gene expression and protein synthesis, 2) mitochondrial damage and 3) the improper regulation of the autophagy programme. In this issue of British Journal of Pharmacology, Galindo and co-workers provide the first evidence for a role of the mPTP in mitochondrial fragmentation and autophagy activation. In a model of 3NP-induced cell death in human neural cells, the authors describe clear functions for mPTP and bax, but not mitochondrial fusion/fission machinery, mitochondrial fragmentation and autophagy (mitophagy). This commentary summarises the significance of this relationship and suggests several points for future development.
Affiliation
Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Departamento de Bioquímica y Biología Molecular y Genética, E. Enfermería y T.O., Universidad de Extremadura, CP 10003, Cáceres, Spain.
Journal Details
This article was published in the following journal.
Name: British journal of pharmacology
ISSN: 1476-5381
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22946678
- DOI: http://dx.doi.org/10.1111/j.1476-5381.2012.02203.x
Medical and Biotech [MESH] Definitions
Models, Statistical
Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.
Mitochondria, Muscle
Mitochondria of skeletal and smooth muscle. It does not include myocardial mitochondria for which MITOCHONDRIA, HEART is available.
Models, Nursing
Theoretical models simulating behavior or activities in nursing, including nursing care, management and economics, theory, assessment, research, and education. Some examples of these models include Orem Self-Care Model, Roy Adaptation Model, and Rogers Life Process Model.
Least-squares Analysis
A principle of estimation in which the estimates of a set of parameters in a statistical model are those quantities minimizing the sum of squared differences between the observed values of a dependent variable and the values predicted by the model.
Mitochondria, Heart
The mitochondria of the myocardium.
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