Actinide chelation: biodistribution and in vivo complex stability of the targeted metal ions.
Summary of "Actinide chelation: biodistribution and in vivo complex stability of the targeted metal ions."
Abstract Because of the continuing use of nuclear fuel sources and heightened threats of nuclear weapon use, the amount of produced and released radionuclides is increasing daily, as is the risk of larger human exposure to fission product actinides. A rodent model was used to follow the in vivo distribution of representative actinides, administered as free metal ions or complexed with chelating agents including diethylenetriaminepentaacetic acid (DTPA) and the hydroxypyridinonate ligands 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO). Different metabolic pathways for the different metal ions were evidenced, resulting in intricate ligand- and metal-dependent decorporation mechanisms. While the three studied chelators are known for their unrivaled actinide decorporation efficiency, the corresponding metal complexes may undergo in vivo decomposition and release metal ions in various biological pools. This study sets the basis to further explore the metabolism and in vivo coordination properties of internalized actinides for the future development of viable therapeutic chelating agents.
Affiliation
Chemical Sciences Division, Glenn T. Seaborg Center, Lawrence Berkeley National Laboratory, Berkeley, CA 94720 USA.
Journal Details
This article was published in the following journal.
Name: Toxicology mechanisms and methods
ISSN: 1537-6524
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22957518
- DOI: http://dx.doi.org/10.3109/15376516.2012.728641
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Therapy of heavy metal poisoning using agents which sequester the metal from organs or tissues and bind it firmly within the ring structure of a new compound which can be eliminated from the body.
Rna Stability
The extent to which an RNA molecule retains its structural integrity and resists degradation by RNASE, and base-catalyzed HYDROLYSIS, under changing in vivo or in vitro conditions.
Nobelium
Nobelium. A man-made radioactive element of the actinide metal series. It has the atomic symbol No, atomic number 102, and atomic weight 259.
Radioimmunotherapy
Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).
Rna-induced Silencing Complex
A multicomponent, ribonucleoprotein complex that cleaves specific mRNAs (RNA, MESSENGER) which are targeted for degradation by homologous dsRNAs (RNA, DOUBLE-STRANDED) during the process of RNA INTERFERENCE. It includes siRNA (RNA, SMALL INTERFERING) that is generated from the specific dsRNA.
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