Near infrared dye indocyanine green doped silica nanoparticles for biological imaging.

09:22 EDT 24th May 2015 | BioPortfolio

Summary of "Near infrared dye indocyanine green doped silica nanoparticles for biological imaging."

Indocyanine green (ICG) is an FDA-approved near infrared (NIR) fluorescent dye used in clinical imaging. However, its applications remain limited due to its short half-life, nonspecific plasma binding, optical instability, and poor aqueous stability. Dye doped silica nanoparticles provide an effective barrier in keeping the dye away from the surrounding environment, but ICG cannot be encapsulated into silica easily by conventional methods. In this study, ICG molecules ion-paired with a cationic polymer polyethylenimine (PEI) were successfully encapsulated into a silica matrix to form ICG doped silica nanoparticles by using the Stöber method. Pairing with PEI reduced self-quenching of fluorescence by preventing the aggregation of ICG molecules in silica nanoparticles. Dye leakage was also reduced to the level of 3-6% loss in 5 days. NIR fluorescence images of ICG doped silica NPs below a 2.0cm thick porcine muscle sample illuminated by NIR light were obtained.

Affiliation

Department of Chemistry, Seoul National University, Seoul 151-747, South Korea.

Journal Details

This article was published in the following journal.

Name: Talanta
ISSN: 1873-3573
Pages: 387-93

Links

PubMed Articles [11850 Associated PubMed Articles listed on BioPortfolio]

Composites of Eu(3+)-Doped Calcium Apatite Nanoparticles and Silica Particles: Comparative Study of Two Preparation Methods.

We synthesized composites of Eu(3+)-doped calcium apatite (CaAp:Eu(3+)) nanoparticles and silica particles via two methods: (i) in situ synthesis of CaAp:Eu(3+) in the presence of silica particles; an...

New paradigm shift for the green synthesis of antibacterial silver nanoparticles utilizing plant extracts.

This review covers general information regarding the green synthesis of antibacterial silver nanoparticles. Owing to their antibacterial properties, silver nanoparticles are widely used in many areas,...

In Vitro Bioactivity and Antimicrobial Tuning of Bioactive Glass Nanoparticles Added with Neem (Azadirachta indica) Leaf Powder.

Silica and phosphate based bioactive glass nanoparticles (58SiO2-33CaO-9P2O5) with doping of neem (Azadirachta indica) leaf powder and silver nanoparticles were prepared and characterised. Bioactive g...

Enhancement of single particle rare earth doped NaYF4: Yb, Er emission with a gold shell.

Upconversion of infrared light to visible light has important implications for bioimaging. However, the small absorption cross-section of rare earth dopants has limited the efficiency of these anti-St...

Effects of intravenously administered indocyanine green on near-infrared cerebral oximetry and pulse oximetry readings.

Intravenously administered indocyanine green (ICG) may cause misreadings of cerebral oximetry and pulse oximetry in patients undergoing carotid endarterectomy under general anesthesia. The present stu...

Clinical Trials [986 Associated Clinical Trials listed on BioPortfolio]

Fluorescence Cholangiography During Cholecystectomy - a RCT

The primary objective is to compare the success rates of intraoperative fluorescent cholangiography using indocyanine green versus conventional X-ray cholangiography for the identification...

Treatment of Patients With Neovascular AMD Using Indocyanine Green-Mediated Photothrombosis (i-MP).

To establish the safety and efficacy of indocyanine green-mediated photothrombosis (i-MP) for the treatment of patients with neovascular age-related macular degeneration.

Surgical Removal of Idiopathic Epiretinal Membrane With and Without the Assistance of Indocyanine Green.

It was the aim of the present study to prospectively compare the functional and morphological outcome of idiopathic epiretinal membrane surgery with and without the assistance of Indocyani...

Brilliant Blue Versus Indocyanine Green

A study of non-inferiority design comparing brilliant blue and indocyanine green as intraoperative dye in macular pucker and macular hole.

Fluorescent Dyes for Lymph Node Mapping

The goal of this clinical research study is to find lymph nodes before surgery using a dye called indocyanine green (IC-Green). Objectives: 1. To determine the feasibility of usi...

Medical and Biotech [MESH] Definitions

A tricarbocyanine dye that is used diagnostically in liver function tests and to determine blood volume and cardiac output.

Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.

Nanoparticles produced from metals whose uses include biosensors, optics, and catalysts. In biomedical applications the particles frequently involve the noble metals, especially gold and silver.

Measurement of the regional temperature of the body or an organ by infrared sensing devices, based on self-emanating infrared radiation.

Diamond nanoparticles that exhibit unique biological, thermal, mechanical, and optoelectronic properties. They have important NANOMEDICINE applications including DRUG DELIVERY SYSTEMS; DIAGNOSTIC IMAGING; protein separation; and BIOSENSING TECHNIQUES.

Search BioPortfolio:
Loading
Advertisement

Relevant Topic

Blood
Latest News Clinical Trials Research Drugs Reports Corporate
Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells.  In vertebrates, it is composed of blo...

Advertisement

Searches Linking to this Article