Numerical simulation of the effect of permeability on the hydrodynamics in a parallel-plate coculture flow chamber.
Summary of "Numerical simulation of the effect of permeability on the hydrodynamics in a parallel-plate coculture flow chamber."
To study the effect of the porous membrane permeability on the hydrodynamics in a parallel-plate coculture flow chamber (PPcFC), we demonstrated the permeability of the porous membrane as a function of some parameters, such as porosity, membrane thickness, pore size and shape of the membrane. The effect of permeability on the flow in the PPcFC was analysed using the commercial software - Fluent. Results showed that the permeability was directly proportional to the thickness, the porosity and the pore size of the membrane, and inversely proportional to the surface shape factor. To ensure the best flow pattern, the inlet velocity range was limited by the membrane permeability and fluid viscosity, and then restricted the available magnitudes of shear rate on the permeable membrane. Our findings are helpful in designing and preparing the biomaterials that have adequate mechanical properties for the functional vascular grafts production, and in using of the flow chamber in various investigations.
Affiliation
a Laboratory of Cardiovascular Diseases, West China Hospital, Sichuan University , Chengdu , P.R. China.
Journal Details
This article was published in the following journal.
Name: Computer methods in biomechanics and biomedical engineering
ISSN: 1476-8259
Pages:
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/22994242
- DOI: http://dx.doi.org/10.1080/10255842.2012.723699
Medical and Biotech [MESH] Definitions
Coculture Techniques
A technique of culturing mixed cell types in vitro to allow their synergistic or antagonistic interactions, such as on CELL DIFFERENTIATION or APOPTOSIS. Coculture can be of different types of cells, tissues, or organs from normal or disease states.
Molecular Dynamics Simulation
A computer simulation developed to study the motion of molecules over a period of time.
Neural Plate
The region in the dorsal ECTODERM of a chordate embryo that gives rise to the future CENTRAL NERVOUS SYSTEM. Tissue in the neural plate is called the neuroectoderm, often used as a synonym of neural plate.
Weightlessness Simulation
Condition under normal Earth gravity where the force of gravity itself is not actually altered but its influence or effect may be modified and studied. (From ASGSB Bull 1992;5(2):27)
Hydrodynamics
The motion of fluids, especially noncompressible liquids, under the influence of internal and external forces.
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