Differential DNA Damage Response in Stem and Progenitor Cells.
Summary of "Differential DNA Damage Response in Stem and Progenitor Cells."
The long lifespan of tissue-specific stem cells suggests that they may respond differently to DNA damage than downstream cells. In this issue of Cell Stem Cell, two groups address this hypothesis by examining DNA damage responses in hematopoietic stem and progenitor cells (Milyavsky et al., 2010; Mohrin et al., 2010).
Affiliation
Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Journal Details
This article was published in the following journal.
Name: Cell stem cell
ISSN: 1875-9777
Pages: 145-147
Links
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20682442
- DOI: http://dx.doi.org/10.1016/j.stem.2010.07.006
Medical and Biotech [MESH] Definitions
Multipotent Stem Cells
Specialized stem cells that are committed to give rise to cells that have a particular function; examples are MYOBLASTS; MYELOID PROGENITOR CELLS; and skin stem cells. (Stem Cells: A Primer [Internet]. Bethesda (MD): National Institutes of Health (US); 2000 May [cited 2002 Apr 5]. Available from: http://www.nih.gov/news/stemcell/primer.htm)
Myeloid Progenitor Cells
Stem cells derived from HEMATOPOIETIC STEM CELLS. Derived from these myeloid progenitor cells are the MEGAKARYOCYTES; ERYTHROID CELLS; MYELOID CELLS; and some DENDRITIC CELLS.
Stem Cells
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Fetal Stem Cells
Cells derived from a FETUS that retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.
Hematopoietic Stem Cells
Progenitor cells from which all blood cells derive.
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