Purpura fulminans: a rare presentation of a common disease.

06:00 EDT 7th August 2010 | BioPortfolio

Summary of "Purpura fulminans: a rare presentation of a common disease."

Malaria is a common health problem in India and contributes about 80% of the total cases in South East Asia. Falciparum malaria is known for its various complications, including cerebral malaria, severe anaemia, acute renal failure, acute lung injury, jaundice (and hepatic involvement), hypoglycaemia and circulatory collapse. We hereby report on a young male who was suffering from complicated falciparum malaria, and had purpura fulminans along with laboratory features suggestive of disseminated intravascular coagulation. He was treated with intravenous (IV) artesunate, low molecular weight heparin followed by warfarin in addition to IV fluids to which he showed gradual response. We have presented this case to make others vigilant enough to suspect malaria in differential diagnosis of purpura fulminans.


Department of Medicine, CSM Medical University, Lucknow, UP, India.

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Name: Tropical doctor
ISSN: 1758-1133


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Medical and Biotech [MESH] Definitions

A severe, rapidly fatal reaction occurring most commonly in children following an infectious illness. It is characterized by large, rapidly spreading skin hemorrhages, fever, or shock. Purpura fulminans often accompanies or is triggered by DISSEMINATED INTRAVASCULAR COAGULATION.

A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS.

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Class I-restricted activation of CD8-POSITIVE LYMPHOCYTES resulting from ANTIGEN PRESENTATION of exogenous ANTIGENS (cross-presentation). This is in contrast to normal activation of these lymphocytes (direct-priming) which results from presentation of endogenous antigens.

Thrombocytopenia occurring in the absence of toxic exposure or a disease associated with decreased platelets. It is mediated by immune mechanisms, in most cases IMMUNOGLOBULIN G autoantibodies which attach to platelets and subsequently undergo destruction by macrophages. The disease is seen in acute (affecting children) and chronic (adult) forms.

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