Advertisement

Topics

Joint Effect of Cigarette Smoking, CFH and LOC387715/HTRA1 Polymorphisms on Polypoidal Choroidal Vasculopathy.

06:00 EDT 7th August 2010 | BioPortfolio

Summary of "Joint Effect of Cigarette Smoking, CFH and LOC387715/HTRA1 Polymorphisms on Polypoidal Choroidal Vasculopathy."

Purpose: To investigate whether the major genetic and environmental risk factors of age-related macular degeneration (AMD), namely CFH Y402H and LOC387715 A69S and cigarette smoking, were also associated with polypoidal choroidal vasculopathy (PCV), and whether the associations of CFH Y402H and LOC387715 A69S with PCV were modified by smoking. Methods: Three hundred and seventy-five Japanese patients with PCV and 847 Japanese who served as population-based controls >/=55-years-of-age were studied. CFH Y402H (rs1061170) and LOC387715 A69S (rs10490924) were genotyped using the Taqman SNP assay. An unconditional logistic regression model was used to analyze the association between age, gender, smoking status, CFH Y402H, LOC387715 A69S, and PCV. The synergy index (SI) was measured to assess gene-smoking and gene-gene interaction as departure from additivity. Results: CFH Y402H, LOC387715 A69S, and cigarette smoking status were all significantly associated with PCV; for CFH Y402H, the adjusted OR for the number of copies of the allele = 1.63 (95% confidence interval [CI]: 1.12-2.36, P < 0.05); for LOC387715 A69S, the adjusted OR = 2.26 (95%
CI:
1.83-2.78, P < 0.0001); and for smoking status (ever vs. never smoked), the adjusted OR = 1.45 (95%
CI:
1.00-2.10, P < 0.05). The joint effect of CFH Y402H and smoking was significantly greater than the additive scale with a SI of 2.41 (95% CI, 1.14-5.10). Conclusion: CFH Y402H and LOC387715 A69S are both significantly associated with PCV. Cigarette smoking is an environmental risk factor for PCV. Our findings suggest possible interactions between CFH 402H and cigarette smoking on PCV.

Affiliation

Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Journal Details

This article was published in the following journal.

Name: Investigative ophthalmology & visual science
ISSN: 1552-5783
Pages:

Links

DeepDyve research library

PubMed Articles [15990 Associated PubMed Articles listed on BioPortfolio]

Joint trajectories of cigarette smoking and depressive symptoms from the mid-twenties to the mid-thirties predicting generalized anxiety disorder.

The current study examines the longitudinal patterns of both cigarette smoking and depressive symptoms as predictors of generalized anxiety disorder (GAD) using data from the Harlem Longitudinal Devel...

Adolescent Light Cigarette Smoking Patterns and Adult Cigarette Smoking.

Light cigarette smoking has had limited research. The purpose of this study was to examine the relationship between light smoking in adolescence with smoking in adulthood.

Longitudinal Associations of Local Cigarette Prices and Smoking Bans with Smoking Behavior in the Multi-Ethnic Study of Atherosclerosis (MESA).

Few studies have examined associations of geographically proximal cigarette prices with within-person changes in smoking outcomes, or assessed interactions between cigarette prices and smoking bans.

Discontinuous Patterns of Cigarette Smoking from Age 18 to 50 in the U.S.: A Repeated-Measures Latent Class Analysis.

Effective cigarette smoking prevention and intervention programming is enhanced by accurate understanding of developmental smoking pathways across the lifespan. This study investigated within-person p...

Genetic polymorphisms in CYP2A6 are associated with a risk of cigarette smoking and predispose to smoking at younger ages.

Nicotine is the main component of cigarettes that causes addiction, which is considered a complex disease, and genetic factors have been proposed to be involved in the development of addiction. The CY...

Clinical Trials [3744 Associated Clinical Trials listed on BioPortfolio]

LOC387715/HTRA1 Variants in Polypoidal Choroidal Vasculopathy in a Korean Population

This study is to investigate whether variants in the LOC387715 locus and the HtrA serine peptidase 1 (HTRA1) gene within the 10q26 locus are associated with polypoidal choroidal vasculopat...

Genetic Polymorphisms Associated With Cigarette Smoking and Risk of Graves’ Disease

Cigarette smoking is a well-recognized risk factor of Graves’ disease and, particularly, Graves’ ophthalmopathy. Hence, germline polymorphisms of detoxification genes and genes belongi...

Nicotine Reinforcement and Smoking-Cue Reactivity: Association With Genetic Polymorphisms

In this study, potential associations between several genetic polymorphisms and nicotine dependence will be examined. The relative reinforcing efficacy of cigarettes using the forced-choic...

Smoking Cessation Effect of Tea Filter Through Inhibition of Nicotine Receptor

Cigarette smoking is the major risk factor for a series of life threatening diseases including cancer and heart attack, which causes millions of deaths each year worldwide. Many of the har...

Effects of Implicit Messaging by Cigarette Pack Color on Smoking Behaviors

The purpose of this study is to examine the effect of changes in cigarette package color and warning label features on smoking behaviors and beliefs about cigarette risks.

Medical and Biotech [MESH] Definitions

Electronic devices that are designed to provide NICOTINE in the form of an inhaled aerosol. They typically are made in the shape of CIGARETTES in order to simulate the experience of CIGARETTE SMOKING.

A cytochrome P-450 monooxygenase that can be induced by polycyclic aromatic xenobiotics in the liver of human and several animal species. This enzyme is of significant clinical interest due to the large number of drug interactions associated with its induction and its metabolism of THEOPHYLLINE. Caffeine is considered to be a model substrate for this enzyme. CYP1A2 activity can also be increased by environmental factors such as cigarette smoking, charbroiled meat, cruciferous vegetables, and a number of drugs including phenytoin, phenobarbital, and omeprazole.

Discontinuation of the habit of smoking, the inhaling and exhaling of tobacco smoke.

Part of the body in humans and primates where the arms connect to the trunk. The shoulder has five joints; ACROMIOCLAVICULAR joint, CORACOCLAVICULAR joint, GLENOHUMERAL joint, scapulathoracic joint, and STERNOCLAVICULAR joint.

Motivational state produced by inconsistencies between simultaneously held cognitions or between a cognition and behavior; e.g., smoking enjoyment and believing smoking is harmful are dissonant.

Quick Search
Advertisement
 


DeepDyve research library

Relevant Topics

Rheumatology
Arthritis Fibromyalgia Gout Lupus Rheumatic Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Diction...

Ophthalmology
Ophthalmology is the branch of medicine that is devoted to the study and treatment of eye diseases. As well as mild visual defects correctable by lenses, ophthalmology is concerned with glaucoma, uveitis and other serious conditions affecting the eye, ...


Searches Linking to this Article