Joint Effect of Cigarette Smoking, CFH and LOC387715/HTRA1 Polymorphisms on Polypoidal Choroidal Vasculopathy.
Summary of "Joint Effect of Cigarette Smoking, CFH and LOC387715/HTRA1 Polymorphisms on Polypoidal Choroidal Vasculopathy."
Purpose: To investigate whether the major genetic and environmental risk factors of age-related macular degeneration (AMD), namely CFH Y402H and LOC387715 A69S and cigarette smoking, were also associated with polypoidal choroidal vasculopathy (PCV), and whether the associations of CFH Y402H and LOC387715 A69S with PCV were modified by smoking. Methods: Three hundred and seventy-five Japanese patients with PCV and 847 Japanese who served as population-based controls >/=55-years-of-age were studied. CFH Y402H (rs1061170) and LOC387715 A69S (rs10490924) were genotyped using the Taqman SNP assay. An unconditional logistic regression model was used to analyze the association between age, gender, smoking status, CFH Y402H, LOC387715 A69S, and PCV. The synergy index (SI) was measured to assess gene-smoking and gene-gene interaction as departure from additivity. Results: CFH Y402H, LOC387715 A69S, and cigarette smoking status were all significantly associated with PCV; for CFH Y402H, the adjusted OR for the number of copies of the allele = 1.63 (95% confidence interval [CI]: 1.12-2.36, P < 0.05); for LOC387715 A69S, the adjusted OR = 2.26 (95%
1.83-2.78, P < 0.0001); and for smoking status (ever vs. never smoked), the adjusted OR = 1.45 (95%
1.00-2.10, P < 0.05). The joint effect of CFH Y402H and smoking was significantly greater than the additive scale with a SI of 2.41 (95% CI, 1.14-5.10). Conclusion: CFH Y402H and LOC387715 A69S are both significantly associated with PCV. Cigarette smoking is an environmental risk factor for PCV. Our findings suggest possible interactions between CFH 402H and cigarette smoking on PCV.
Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
This article was published in the following journal.
Name: Investigative ophthalmology & visual science
- PubMed Source: http://www.ncbi.nlm.nih.gov/pubmed/20688737
- DOI: http://dx.doi.org/10.1167/iovs.09-4948
Medical and Biotech [MESH] Definitions
Cytochrome P-450 Cyp1a2
A cytochrome P-450 monooxygenase that can be induced by polycyclic aromatic xenobiotics in the liver of human and several animal species. This enzyme is of significant clinical interest due to the large number of drug interactions associated with its induction and its metabolism of THEOPHYLLINE. Caffeine is considered to be a model substrate for this enzyme. CYP1A2 activity can also be increased by environmental factors such as cigarette smoking, charbroiled meat, cruciferous vegetables, and a number of drugs including phenytoin, phenobarbital, and omeprazole.
Discontinuation of the habit of smoking, the inhaling and exhaling of tobacco smoke.
Motivational state produced by inconsistencies between simultaneously held cognitions or between a cognition and behavior; e.g., smoking enjoyment and believing smoking is harmful are dissonant.
Joint Capsule Release
Surgical procedure to relax the JOINT CAPSULE tissues in a joint that has a reduced range of motion due to CONTRACTURE or TISSUE ADHESIONS or joint deformities.
Lack of stability of a joint or joint prosthesis. Factors involved are intra-articular disease and integrity of extra-articular structures such as joint capsule, ligaments, and muscles.
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