Track topics on Twitter Track topics that are important to you
Purpose: To investigate whether the major genetic and environmental risk factors of age-related macular degeneration (AMD), namely CFH Y402H and LOC387715 A69S and cigarette smoking, were also associated with polypoidal choroidal vasculopathy (PCV), and whether the associations of CFH Y402H and LOC387715 A69S with PCV were modified by smoking. Methods: Three hundred and seventy-five Japanese patients with PCV and 847 Japanese who served as population-based controls >/=55-years-of-age were studied. CFH Y402H (rs1061170) and LOC387715 A69S (rs10490924) were genotyped using the Taqman SNP assay. An unconditional logistic regression model was used to analyze the association between age, gender, smoking status, CFH Y402H, LOC387715 A69S, and PCV. The synergy index (SI) was measured to assess gene-smoking and gene-gene interaction as departure from additivity. Results: CFH Y402H, LOC387715 A69S, and cigarette smoking status were all significantly associated with PCV; for CFH Y402H, the adjusted OR for the number of copies of the allele = 1.63 (95% confidence interval [CI]: 1.12-2.36, P < 0.05); for LOC387715 A69S, the adjusted OR = 2.26 (95%
1.83-2.78, P < 0.0001); and for smoking status (ever vs. never smoked), the adjusted OR = 1.45 (95%
1.00-2.10, P < 0.05). The joint effect of CFH Y402H and smoking was significantly greater than the additive scale with a SI of 2.41 (95% CI, 1.14-5.10). Conclusion: CFH Y402H and LOC387715 A69S are both significantly associated with PCV. Cigarette smoking is an environmental risk factor for PCV. Our findings suggest possible interactions between CFH 402H and cigarette smoking on PCV.
Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
This article was published in the following journal.
Name: Investigative ophthalmology & visual science
The number of studies on adiponectin, GPx-1 gene polymorphisms, and nonalcoholic fatty liver disease (NAFLD) susceptibility is increasing, but none have investigated the effect of cigarette smoking in...
To evaluate the frequency of 12 single nucleotide polymorphisms (SNPs) of complement factor H (CFH) and LOC387715/ARMS2/HRTA1 and their association with some of the presenting clinical features of neo...
Cigarette smoking has been shown to be a health hazard. In addition to being considered a negative lifestyle behavior, studies have shown that cigarette smoking has been linked to genetic underpinning...
E-cigarette use has been linked to onset of cigarette smoking among adolescents, but some commentators have suggested that this simply reflects high-risk adolescents being more likely to use e-cigaret...
E-cigarette use by adolescents has been related to onset of cigarette smoking but there is little knowledge about the process(es) through which this occurs. Accordingly, we tested the role of cognitiv...
This study is to investigate whether variants in the LOC387715 locus and the HtrA serine peptidase 1 (HTRA1) gene within the 10q26 locus are associated with polypoidal choroidal vasculopat...
Cigarette smoking is a well-recognized risk factor of Graves’ disease and, particularly, Graves’ ophthalmopathy. Hence, germline polymorphisms of detoxification genes and genes belongi...
Cigarette smoking is the major risk factor for a series of life threatening diseases including cancer and heart attack, which causes millions of deaths each year worldwide. Many of the har...
The purpose of this study is to examine the effect of changes in cigarette package color and warning label features on smoking behaviors and beliefs about cigarette risks.
This proposed 2-year questionnaire study examines views and attitudes regarding health risks of cigarette smoking, smoking patterns and motivators for cessation in smokers who suffer from ...
A cytochrome P-450 monooxygenase that can be induced by polycyclic aromatic xenobiotics in the liver of human and several animal species. This enzyme is of significant clinical interest due to the large number of drug interactions associated with its induction and its metabolism of THEOPHYLLINE. Caffeine is considered to be a model substrate for this enzyme. CYP1A2 activity can also be increased by environmental factors such as cigarette smoking, charbroiled meat, cruciferous vegetables, and a number of drugs including phenytoin, phenobarbital, and omeprazole.
Discontinuation of the habit of smoking, the inhaling and exhaling of tobacco smoke.
Motivational state produced by inconsistencies between simultaneously held cognitions or between a cognition and behavior; e.g., smoking enjoyment and believing smoking is harmful are dissonant.
Surgical procedure to relax the JOINT CAPSULE tissues in a joint that has a reduced range of motion due to CONTRACTURE or TISSUE ADHESIONS or joint deformities.
Lack of stability of a joint or joint prosthesis. Factors involved are intra-articular disease and integrity of extra-articular structures such as joint capsule, ligaments, and muscles.
Arthritis Fibromyalgia Gout Lupus Rheumatic Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Diction...
Ophthalmology is the branch of medicine that is devoted to the study and treatment of eye diseases. As well as mild visual defects correctable by lenses, ophthalmology is concerned with glaucoma, uveitis and other serious conditions affecting the eye, ...